Cyclohex-1-enyl-alanin | 16055-15-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cyclohex-1-enyl-alanin
• 英文别名: 2-amino-3-cyclohex-1-enyl-propionic acid；2-Amino-3-cyclohex-1-enyl-propionsaeure；2-Amino-3-(cyclohexen-1-yl)propanoic acid
• CAS: 16055-15-5
• 化学式: C₉H₁₅NO₂
• mdl: MFCD09842074
• 分子量: 169.224
• InChiKey: HENPBTOHCYVWAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 Cyclohex-1-enyl-alanin
  参考文献：
  名称：

  Synthesis of 2-Cyclohexene-1-glycine and 1-Cyclohexene-1-alanine, Inhibitory Amino Acid Analogs

  摘要：

  DOI：

  10.1021/ja01576a037

文献信息

• Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
  申请人：Ryan, James Walter

  公开号：EP0073143A2

  公开（公告）日：1983-03-02

  Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula wherein R, and/or R3 form complex amides and imides thereof, X = S, O or NR3, R4 and Rs form with -N-C- a 4-6 membered ring structure as described and the other R substituents are selected from a variety of disclosed groups.

  已公开的新型血管紧张素转换酶抑制剂具有通式 其中 R 和/或 R3 形成其复合酰胺和亚胺，X = S、O 或 NR3，R4 和 Rs 与 -N-C- 形成所述的 4-6 分子环结构，其他 R 取代基选自各种已公开的基团。
• Method for producing L-Phenylalanine
  申请人：Ajinomoto Co., Inc.

  公开号：EP1134283A1

  公开（公告）日：2001-09-19

  A method for producing L-phenylalanine, comprising the steps of: culturing a bacterium belonging to the genus Methylophilus which has an ability to produce L-phenylalanine and is resistant to a phenylalanine analog, in a culture medium to produce and accumulate L-phenylalanine in a culture, and recovering L-phenylalanine from the culture.

  一种生产 L-苯丙氨酸的方法，包括以下步骤 在培养基中培养一种属于嗜甲氧菌属的细菌，该细菌具有生产 L-苯丙氨酸的能力，并对苯丙氨酸类似物具有抗性，以在培养物中生产和积累 L-苯丙氨酸，以及 从培养液中回收 L-苯丙氨酸。
• HSF-like transcription factor, TBF1, is a major molecular switch for growth-to-defense transition in plants
  申请人：DUKE UNIVERSITY

  公开号：US10017773B2

  公开（公告）日：2018-07-10

  The present invention relates to new methods to study and control the expression of plant genes, particularly nucleotide sequences located downstream from regions comprising binding sites for transcription factors, such as the cis-element translocon 1 (TL1) comprising GAAGAAGAA and similar sequences. The invention relates to isolated nucleotide sequences comprising a regulatory region comprising a promoter operably-linked to one or more upstream open reading frames (uORFs) and one or more downstream open reading frames (dORFs) encoding one or more functional polypeptides, including transcription factors such as TBF1, reporter polypeptides, and polypeptides conferring resistance to drugs, resistance of plants viral, bacterial, or fungal pathogens, and polypeptides involved in the growth of plants. Related aspects include the use of a region which encodes one or more polypeptides designated uORF1 and uORF2 from Arabidopsis plants, natural and synthetic variants of these polypeptides, and their homologues and orthologues isolated from other plant species, including crop plants, plus vectors, cells, plant propagation material, transgenic plants, and seeds comprising nucleic acids comprising said all or portions of said regulatory region. Other aspects relate to methods of using these regulatory elements to generate and screen for transgenic plants having improved resistance microbial and viral plant pathogens, and engineered cells and plants comprising these one or more of these genetic elements to facilitate the production of proteins for use in structure/function studies, in industrial, medical, and agricultural applications, particularly in the discovery of metabolic pathways involved in the and development of disease-resistant plants.

  本发明涉及研究和控制植物基因表达的新方法，特别是位于包含转录因子结合位点的区域下游的核苷酸序列，例如包含GAAGAAGAA和类似序列的顺式元件转座子1（TL1）。本发明涉及分离的核苷酸序列，该序列包含一个调控区，该调控区包括一个启动子，该启动子可操作地连接到一个或多个上游开放阅读框（uORF）和一个或多个下游开放阅读框（dORF），该下游开放阅读框编码一种或多种功能性多肽，包括转录因子（如 TBF1）、报告基因多肽、赋予抗药性的多肽、植物病毒、细菌或真菌病原体的抗性以及参与植物生长的多肽。相关方面包括使用编码来自拟南芥植物的一种或多种多肽的区域，指定为uORF1和uORF2，这些多肽的天然和合成变体，以及它们的同源物和从其他植物物种（包括作物植物）分离的直向同源物，加上载体、细胞、植物繁殖材料、转基因植物和种子，这些植物包括包含所述全部或部分调控区域的核酸。其它方面涉及使用这些调控元件产生和筛选具有更好的抗微生物和病毒植物病原体能力的转基因植物的方法，以及包含这些一个或多个遗传元件的工程细胞和植物，以促进蛋白质的生产，用于结构/功能研究、工业、医学和农业应用，特别是用于发现抗病植物的代谢途径和开发。
• Method for producing L-phenylalanine
  申请人：Ajinomoto Co., Inc.

  公开号：US20010044139A1

  公开（公告）日：2001-11-22

  A method for producing L-phenylalanine, comprising the steps of: culturing a bacterium belonging to the genus Methylophilus which has an ability to produce L-phenylalanine and is resistant to a phenylalanine analog, in a culture medium to produce and accumulate L-phenylalanine in a culture, and recovering L-phenylalanine from the culture.

  一种生产 L-苯丙氨酸的方法，包括以下步骤 在培养基中培养一种属于嗜甲氧菌属的细菌，该细菌具有生产 L-苯丙氨酸的能力，并对苯丙氨酸类似物具有抗性，以在培养物中生产和积累 L-苯丙氨酸，以及 从培养液中回收 L-苯丙氨酸。
• Method of producing L-phenylalanine by fermentation, and bacteria therefor
  申请人：AJINOMOTO CO., INC.

  公开号：EP0138526B1

  公开（公告）日：1989-04-26