1,4-Diphenylpyrrolo[3,2-b]pyridin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1,4-Diphenylpyrrolo[3,2-b]pyridin-5-one
• 化学式: C₁₉H₁₄N₂O
• 分子量: 286.3
• InChiKey: CATXIZNYTWMVLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Bicyclic oxopyridine and oxopyrimidine derivatives
  申请人：——

  公开号：US20040254200A1

  公开（公告）日：2004-12-16

  Compounds of formulae (1a) and (1b) are described: in which the dashed line represents an optional bond; A is a —N=atom or a —N(R b )—, —C(R b )═ or —C(R b )(R C )— group; R a , R b and R c is each independently a hydrogen atom or an optionally substituted C 1-6 alkyl group; X is an —O— or —S— atom or —NH— group or substituted N atom; each Y is independently a N atom or CH group or substituted C atom; n is zero or the integer 1; Alk 1 is an optionally substituted aliphatic or heteroaliphatic chain L 1 is a covalent bond or a linker atom or group; Cy 1 is a hydrogen atom or an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; Ar is an optionally substituted aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof; The compounds are potent inhibitors of p38 kinase and are use in the prophylaxis or treatment of p38 kinase mediated diseases or disorders, such as rheumatoid arthritis. 1

  描述了式（1a）和（1b）的化合物：其中虚线代表可选键；A是-N=原子或-N（Rb）-，-C（Rb）-或-C（Rb）（RC）-基团；Ra，Rb和Rc分别独立地是氢原子或可选地取代的C1-6烷基基团；X是-O-或-S-原子或-NH-基团或取代的N原子；每个Y独立地是N原子或CH基团或取代的C原子；n为零或整数1；Alk1是可选地取代的脂肪或杂脂肪链；L1是共价键或连接原子或基团；Cy1是氢原子或可选地取代的环脂肪，多环脂肪，杂环脂肪，多杂环脂肪，芳香或杂芳香基团；Ar是可选地取代的芳香或杂芳香基团；以及其盐，溶剂合物，水合物和N-氧化物。这些化合物是p38激酶的有效抑制剂，并用于预防或治疗p38激酶介导的疾病或障碍，如类风湿性关节炎。
• Far field light microscopical method system and computer program product for analysing at least one object having a subwavelength size
  申请人：Cremer Christopher

  公开号：US20050059681A1

  公开（公告）日：2005-03-17

  The present invention relates to a far field light microscopical method, respectively a system and a computer program product for analysing at least one object having a subwavelength size in at least one spatial direction to obtain spatial information of the object, in particular size and topology thereof, comprising the steps of:—labelling the object(s) with one or more suitable optical markers;—providing suitably structured illumination light to at least partially illuminate the object(s);—subjecting the object(s) to the structured illumination light;—detecting an optical response of the object(s);—obtaining the spatial information of the object(s) by comparing the obtained response with simulation data of an optical response of object(s) having known spatial information.

  本发明涉及一种远场光显微学方法，分别是一种系统和一种计算机程序产品，用于分析至少一个空间方向上具有亚波长尺寸的至少一个物体，以获得该物体的空间信息，特别是其尺寸和拓扑结构，包括以下步骤：-用一个或多个合适的光学标记标记物体；-提供合适的结构化照明光，至少部分照亮物体；-将物体置于结构化照明光下；-检测物体的光学响应；-通过将获得的响应与具有已知空间信息的物体的光学响应的模拟数据进行比较，获得物体的空间信息。
• US7176215B2
  申请人：——

  公开号：US7176215B2

  公开（公告）日：2007-02-13