4-Chloro-5-fluoro-2-[3-(furan-2-yl)azetidin-3-yl]oxybenzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-Chloro-5-fluoro-2-[3-(furan-2-yl)azetidin-3-yl]oxybenzonitrile
• 化学式: C₁₄H₁₀ClFN₂O₂
• 分子量: 292.69
• InChiKey: XPDKIIYWSOGKMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  58.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NOVEL PHENYLHETEROAZETIDINES, USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS<br/>[FR] NOUVELLES PHENYLHETEROAZETIDINES UTILES COMME INHIBITEURS DE LA SYNTHASE D'OXYDE NITRIQUE
  申请人：ASTRAZENECA AB

  公开号：WO2002012187A1

  公开（公告）日：2002-02-14

  There are provided novel compounds of formula (I) wherein R?1, R2, R3, R4, R5, R6, R7, R8, R9¿, W, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions bontaining them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.