5-(4-Carboxy-4-methylpentyl)sulfinyl-2,2-dimethylpentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(4-Carboxy-4-methylpentyl)sulfinyl-2,2-dimethylpentanoic acid
• 化学式: C₁₄H₂₆O₅S
• 分子量: 306.42
• InChiKey: CCNGRRPVCHALDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
  申请人：——

  公开号：US20030022865A1

  公开（公告）日：2003-01-30

  The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涉及新型亚砜和双亚砜化合物，含有亚砜和双亚砜化合物的组合物，以及用于治疗和预防心血管疾病、脂质代谢异常、蛋白质代谢异常和葡萄糖代谢紊乱的方法，包括给予含有醚化合物的组合物。本发明的化合物、组合物和方法也适用于治疗和预防阿尔茨海默病、综合征X、过氧化物酶体增殖物激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾脏疾病、癌症、炎症和阳痿。在某些实施例中，本发明的化合物、组合物和方法与其他治疗药物，如降胆固醇和降血糖药物一起使用，可以用于联合治疗。
• SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
  申请人：Esperion Therapeutics Inc.

  公开号：EP1366024A2

  公开（公告）日：2003-12-03
• US6673780B2
  申请人：——

  公开号：US6673780B2

  公开（公告）日：2004-01-06
• [EN] SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES<br/>[FR] COMPOSES DE SULFOXYDE ET DE BIS-SULFOXYDE ET COMPOSITIONS POUR REGULER LE CHOLESTEROL, ET APPLICATIONS ASSOCIEES
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2002030882A2

  公开（公告）日：2002-04-18

  The present invention relates to sulfoxide and bis-sulfoxide compounds of formula I, formula II, or formula III (in which the variables are as defined in the claims), compositions comprising sulphoxide and bissulphoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.