4-(3-fluoro-4-methoxyphenyl)-4-oxo-2-[(trifluoroacetyl)-amino]-butanoic acid | 204456-32-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-(3-fluoro-4-methoxyphenyl)-4-oxo-2-[(trifluoroacetyl)-amino]-butanoic acid
• 英文别名: N-trifluoroacetyl-2-amino-4-oxo-4-(3'-fluoro-4'-methoxyphenyl)-butanoic acid；4-(3-Fluoro-4-methoxyphenyl)-4-oxo-2-[(2,2,2-trifluoroacetyl)amino]butanoic acid
• CAS: 204456-32-6
• 化学式: C₁₃H₁₁F₄NO₅
• 分子量: 337.228
• InChiKey: XBIAKZYGVXKYHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity
  申请人：——

  公开号：US20030195257A1

  公开（公告）日：2003-10-16

  Formula (I) compounds are described, where the groups are defined in the description, as well as processes for their preparation and their use as medicaments, particularly as selective phosphodiesterase IV inhibitors. 1

  描述了Formula (I)化合物，其中群在描述中定义，以及它们的制备过程和用途，特别是作为选择性磷酸二酯酶IV抑制剂的药物。
• 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：US20030158266A1

  公开（公告）日：2003-08-21

  2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.

  2-氨基四氢萘胺、其制备方法和药物组合物，用于预防和治疗炎症性病变（尤其是脓毒性休克）和/或自身免疫性病变，在这些病变中，炎性细胞因子的致病作用已经得到确认。
• N-SUBSTITUTED-2-AMINO-4-PHENYL-4-OXO-BUTANOIC ACID DERIVATIVES WITH KYNURENINE-3-HYDROXYLASE INHIBITORY ACTIVITY
  申请人：PHARMACIA & UPJOHN S.p.A.

  公开号：EP0931056A1

  公开（公告）日：1999-07-28
• COMPOUNDS USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY
  申请人：SIGMA-TAU IndustrieFarmaceutiche Riunite S.p.A.

  公开号：EP1292563A2

  公开（公告）日：2003-03-19
• US6207709B1
  申请人：——

  公开号：US6207709B1

  公开（公告）日：2001-03-27