2-(ethyl-{3-[1-(4-fluoro-phenyl)-1H-indol-5-yl]-1,1-dimethyl-prop-2-ynyl}-amino)-ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-(ethyl-{3-[1-(4-fluoro-phenyl)-1H-indol-5-yl]-1,1-dimethyl-prop-2-ynyl}-amino)-ethanol
• 英文别名: 2-[ethyl-[4-[1-(4-fluorophenyl)indol-5-yl]-2-methylbut-3-yn-2-yl]amino]ethanol
• 化学式: C₂₃H₂₅FN₂O
• 分子量: 364.463
• InChiKey: IRLTZBBKARMUOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  28.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Trifluoro-methanesulfonic acid 1-(4-fluoro-phenyl)-1H-indol-5-yl ester 、 2-[(1,1-Dimethyl-prop-2-ynyl)-ethyl-amino]-ethanol 以to Yield 2-(Ethyl-{3-[1-(4-fluoro-phenyl)-1H-indol-5-yl]-1,1-dimethyl-prop-2-ynyl}-amino)-ethanol as orange viscous oil, MS的产率得到2-(ethyl-{3-[1-(4-fluoro-phenyl)-1H-indol-5-yl]-1,1-dimethyl-prop-2-ynyl}-amino)-ethanol
  参考文献：
  名称：

  Indole and dihydroindole derivatives

  摘要：

  本发明涉及吲哚衍生物、二氢吲哚衍生物及其药学上可接受的盐和/或药学上可接受的酯。这些化合物可用于治疗和/或预防与2,3-氧化齐墨醇-鲑烯醇环化酶相关的疾病，如高胆固醇血症、高脂血症、动脉硬化、血管疾病、真菌感染、胆结石、肿瘤和/或过度增殖性疾病，并用于治疗和/或预防糖耐量受损和糖尿病。

  公开号：

  US20020103247A1

文献信息

• INDOLE AND DIHYDROINDOLE DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1349833A1

  公开（公告）日：2003-10-08
• US6503907B2
  申请人：——

  公开号：US6503907B2

  公开（公告）日：2003-01-07
• [EN] INDOLE AND DIHYDROINDOLE DERIVATIVES<br/>[FR] DERIVES D'INDOLE ET DE DIHYDROINDOLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002044149A1

  公开（公告）日：2002-06-06

  The present invention relates to compounds of formula (I) wherein U, A?1, A2, A3, A4, A5, A6, A7¿, L, V, X, n and the bond ===== between the carbon atom Ca and the carbon atom Cb are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hyper cholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
• Indole and dihydroindole derivatives
  申请人：——

  公开号：US20020103247A1

  公开（公告）日：2002-08-01

  The present invention relates to indole derivatives, dihydroindole derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

  本发明涉及吲哚衍生物、二氢吲哚衍生物及其药用可接受的盐和/或药用可接受的酯。这些化合物可用于治疗和/或预防与2,3-氧化齐墩果甾醇-鲍甲酚环化酶相关的疾病，如高胆固醇血症、高脂血症、动脉硬化、血管疾病、真菌病、胆结石、肿瘤和/或过度增生性疾病，以及治疗和/或预防糖耐量受损和糖尿病。