2-Amino-5-(diaminomethylideneamino)pentanoic acid;2-hydroxypropane-1,2,3-tricarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-5-(diaminomethylideneamino)pentanoic acid;2-hydroxypropane-1,2,3-tricarboxylic acid
• 化学式: C12H22N4O9
• 分子量: 366.32
• InChiKey: SGJSPXDVZJIWEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  260
• 氢给体数：
  8
• 氢受体数：
  11

文献信息

• BIOLUMINESCENCE IMAGING OF MYELOPEROXIDASE ACTIVITY IN VIVO, METHODS, COMPOSITIONS AND APPARATUSES THEREFOR
  申请人：Sharma Vijay

  公开号：US20110250145A1

  公开（公告）日：2011-10-13

  Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.

  公开了成像受试者中过氧化物酶活性分布的方法。这些方法包括使用生物发光底物，包括发光酰胺和波长移位的发光酰胺类似物。发光酰胺类似物可以发射比发光酰胺更长波长的生物发光过氧化物酶底物，被证明对于体内成像过氧化物酶活性是有用的。所公开的方法可用于成像炎症部位和其他与体内异常MPO活性水平相关的病理条件。还公开了发光酰胺类似物的合成方法。
• [EN] ZINC-ARGININE-HALIDE COMPLEX<br/>[FR] COMPLEXE ZINC-ARGININE-HALOGÉNURE
  申请人：COLGATE PALMOLIVE CO

  公开号：WO2020131665A1

  公开（公告）日：2020-06-25

  The disclosure provides a zinc-arginine complex, methods of making the same, and methods of using the same in oral care compositions.

  本公开提供了一种锌-精氨酸复合物，制备该复合物的方法以及在口腔护理组合物中使用该复合物的方法。
• Orally-ingestible nutrition compositions having improved palatability
  申请人：SANDOZ NUTRITION LTD.

  公开号：EP0567433A1

  公开（公告）日：1993-10-27

  An orally-ingestible nutrition composition having improved taste comprises a low pH (< 7.0) form of an amino acid selected from arginine, valine and compounds associated with the synthesis of polyamines. Preferred low pH forms are salts such as arginine phosphate and mixtures thereof with arginine citrate. Preferred nutrition compositions also comprise encapsulated polyunsaturated fatty acid.

  一种口服易消化营养组合物具有更好的口感，它包含一种低 pH 值（< 7.0）形式的氨基酸，这种氨基酸选自精氨酸、缬氨酸和与多胺合成有关的化合物。首选的低 pH 值形式是精氨酸磷酸酯等盐类及其与精氨酸柠檬酸盐的混合物。优选的营养组合物还包括封装的多不饱和脂肪酸。
• Apo2 ligand/TRAIL formulations
  申请人：Genentech, Inc.

  公开号：EP2322165A1

  公开（公告）日：2011-05-18

  The inventions include Apo2L/TRAIL formulations and methods of using such formulations. Lyophilized and crystal formulations of Apo-2L/TRAIL which are stable and have improved Apo2L/TRAIL trimer formation are provided. Methods of making Apo-2L/TRAIL formulations, as well as devices and kits containing such formulations are also provided.

  本发明包括载脂蛋白 2L/TRAIL制剂和使用这种制剂的方法。本发明提供了稳定且具有更好的 Apo2L/TRAIL 三聚体形成的 Apo2L/TRAIL 冻干和晶体制剂。还提供了制造 Apo-2L/TRAIL 制剂的方法，以及含有此类制剂的设备和试剂盒。
• Liquid pharmaceutical composition comprising pemetrexed
  申请人：SYNTHON B.V.

  公开号：US10188655B2

  公开（公告）日：2019-01-29

  The present invention relates to a liquid pharmaceutical composition suitable for parenteral administration comprising: a) pemetrexed diacid; b) at least one organic amine; c) at least one antioxidant; d) 10-200 mg/ml of propylene glycol; and e) one or more parenteral solvents, wherein the preparation thereof is conducted in an atmosphere of inert gas and wherein the organic amine(s) is present in an amount sufficient to reach a pH of the composition in the range from 8.3 to 9.1 The invention further relates to the use of said liquid pharmaceutical composition as medicament in the treatment of malignant pleural mesothelioma and non-small cell lung cancer.

  本发明涉及一种适合肠外给药的液体药物组合物，其中包括 a) 培美曲塞二酸 b) 至少一种有机胺 c) 至少一种抗氧化剂 d) 10-200 毫克/毫升的丙二醇；以及 e) 一种或多种肠外溶剂、 其中，制备过程在惰性气体环境中进行，有机胺的含量足以使组合物的 pH 值在 8.3 至 9.1 之间 本发明还涉及将所述液体药物组合物用作治疗恶性胸膜间皮瘤和非小细胞肺癌的药物。