2-[4-(1-Methyl-6-oxo-4-pyrimidin-4-ylpyrimidin-2-yl)morpholin-2-yl]benzonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-[4-(1-Methyl-6-oxo-4-pyrimidin-4-ylpyrimidin-2-yl)morpholin-2-yl]benzonitrile
• 化学式: C₂₀H₁₈N₆O₂
• 分子量: 374.4
• InChiKey: HJVFOWMJHMSRQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  94.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• 3-Substituted-4-pyrimidone derivatives
  申请人：Uehara Fumiaki

  公开号：US20050130967A1

  公开（公告）日：2005-06-16

  A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1: wherein R 1 represents a C 1 -C 12 alkyl group which may be substituted; R represents, for example, a group represented by the following formula (II): wherein R2 and R 3 independently represent a hydrogen atom or a C 1 -C 8 alkyl group; R 4 represents a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, and having 5 to 10 ring-constituting atoms in total.

  一种由式(I)表示的吡啶酮衍生物或其盐，或其溶剂化物或水合物，具有对tau蛋白激酶1的抑制活性：其中，R1代表可取代的C1-C12烷基；R代表例如由以下式子（II）表示的基团：其中，R2和R3独立地表示氢原子或C1-C8烷基；R4代表可取代的苯环、可取代的萘环、可取代的萘烷环、可取代的四氢萘环或选择自氧原子、硫原子和氮原子组成的1至4个杂环原子，并且总共有5至10个环构成原子的可选取代的杂环。
• 3-SUBSTITUTED-4-PYRIMIDONE DERIVATIVES
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1427709B1

  公开（公告）日：2005-12-14
• US7572793B2
  申请人：——

  公开号：US7572793B2

  公开（公告）日：2009-08-11
• [EN] 3-SUBSTITUTED-4-PYRIMIDONE DERIVATIVES<br/>[FR] DERIVES DE 3-SUBSTITUTE-4-PYRIMIDONE
  申请人：MITSUBISHI PHARMA CORP

  公开号：WO2003027080A1

  公开（公告）日：2003-04-03

  A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1:wherein R1 represents a C1-C12 alkyl group which may be substituted;R represents, for example, a group represented by the following formula (II):wherein R2 and R3 independently represent a hydrogen atom or a C1-C8 alkyl group; R4 represents a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom and nitrogen atom, and having 5 to 10 ring-constituting atoms in total.