(2R,4S,5R)-5-[(6-amino-5-nitropyrimidin-4-yl)amino]-4-hydroxy-2-(hydroxymethyl)oxolan-3-one

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: (2R,4S,5R)-5-[(6-amino-5-nitropyrimidin-4-yl)amino]-4-hydroxy-2-(hydroxymethyl)oxolan-3-one
• 化学式: C9H11N5O6
• 分子量: 285.21
• InChiKey: MMFUTEMLQCJIRK-WCSIQHINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  176
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations
  申请人：Wilde G. Richard

  公开号：US20080090774A1

  公开（公告）日：2008-04-17

  The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.

  该发明涵盖了核苷酸化合物、包含这些化合物的组合物以及通过给予这些化合物或组合物治疗或预防与mRNA无意义突变相关的疾病的方法。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH
  申请人：Almstead Neil G.

  公开号：US20110046136A1

  公开（公告）日：2011-02-24

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由核酸序列编码的功能性蛋白质，其中包括一个无意义突变。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能性蛋白质的方法，以及利用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH
  申请人：PTC THERAPEUTICS, INC

  公开号：US20160199357A1

  公开（公告）日：2016-07-14

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由包含无意义突变的核酸序列编码的功能蛋白质。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能蛋白质的方法，并使用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• NUCLEOSIDE ANALOGUES TO INHIBIT THE MAIN PROTEASE OF A CORONAVIRUS
  申请人：Institut de Recherche en Semiochimie et Ethologie Appliquée

  公开号：EP3912628A1

  公开（公告）日：2021-11-24

  The present invention is directed to nucleoside analogues to inhibit the main protease of a coronavirus. In particular the present invention relates to a composition comprising (i) a compound selected from the group consisting of clitocine, a pharmacophore for clitocine, tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or an acceptable salt thereof, and (ii) a pharmaceutically acceptable vehicle, a carrier, an excipient or a diluent, for use in the prevention and/or the treatment of an infection by a virus from the Coronaviridae family or an illness related to such infection, in a host, in particular a mammalian host.

  本发明涉及抑制冠状病毒主要蛋白酶的核苷类似物。特别是本发明涉及一种组合物，该组合物包含(i) 选自以下组别的化合物：氯妥昔、氯妥昔的药代物、同分异构体、中间体、外消旋体、对映体、非对映体或其混合物，或其可接受的盐、和 (ii) 一种药学上可接受的载体、载体、赋形剂或稀释剂，用于预防和/或治疗宿主，特别是哺乳动物宿主受冠状病毒科病毒感染或与这种感染有关的疾病。
• US7291603B2
  申请人：——

  公开号：US7291603B2

  公开（公告）日：2007-11-06