montanacin F

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: montanacin F
• 英文别名: 2-[(11R)-11-[(2R,5R)-5-[(1S,10S)-1,10-dihydroxytridecyl]oxolan-2-yl]-11-hydroxyundecyl]-4-(2-oxopropyl)-2H-furan-5-one
• 化学式: C₃₅H₆₂O₇
• 分子量: 594.873
• InChiKey: ISIBSQUCPZJLHC-RJYUOKCKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  42
• 可旋转键数：
  26
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  甲氧基-三氟甲基苯 、 montanacin F 在 吡啶 作用下， 以 四氯化碳 、 二氯甲烷 为溶剂， 生成 (S)-α-methoxy-α-trifluoromethyl-phenylacetic acid ester of montanacin F
  参考文献：
  名称：

  Annonaceous acetogenins from the Leaves of Annona montana

  摘要：

  A novel Annonaceous acetogenin, montanacin F. with a new type of terminal lactone unit. was isolated from the leaves of Annona montana. Its structure was determined on the basis of spectral evidences and chemical methods. and a possible biosynthetic pathway was discussed. In addition, the cytotoxicity of montanacin F was evaluated in vitro against Lewis lung carcinoma (LLC) tumor cell lines. Furthermore, the previously isolated cytotoxic acetogenin annonacin against LLC was examined for in vivo antitumor activity with LLC tumor cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00303-0

文献信息

• Annonaceous acetogenins from the Leaves of Annona montana
  作者：Li-Quan Wang、Byung-Sun Min、Yan Li、Norio Nakamura、Guo-Wei Qin、Can-Jun Li、Masao Hattori

  DOI：10.1016/s0968-0896(01)00303-0

  日期：2002.3

  A novel Annonaceous acetogenin, montanacin F. with a new type of terminal lactone unit. was isolated from the leaves of Annona montana. Its structure was determined on the basis of spectral evidences and chemical methods. and a possible biosynthetic pathway was discussed. In addition, the cytotoxicity of montanacin F was evaluated in vitro against Lewis lung carcinoma (LLC) tumor cell lines. Furthermore, the previously isolated cytotoxic acetogenin annonacin against LLC was examined for in vivo antitumor activity with LLC tumor cells. (C) 2002 Elsevier Science Ltd. All rights reserved.