N-[2-[4-(2-(R)-amino-5-guanidino-pentanoyl)-piperazin-1-yl]-1,1-dimethyl-2-oxo-ethyl]-2,4-dichloro-3-(2-methyl-quinolin-8-yloxymethyl)-benzenesulfonamide | 635695-80-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[2-[4-(2-(R)-amino-5-guanidino-pentanoyl)-piperazin-1-yl]-1,1-dimethyl-2-oxo-ethyl]-2,4-dichloro-3-(2-methyl-quinolin-8-yloxymethyl)-benzenesulfonamide
• 英文别名: 2-[(4R)-4-amino-5-[4-[2-[[2,4-dichloro-3-[(2-methylquinolin-8-yl)oxymethyl]phenyl]sulfonylamino]-2-methylpropanoyl]piperazin-1-yl]-5-oxopentyl]guanidine
• CAS: 635695-80-6
• 化学式: C₃₁H₄₀Cl₂N₈O₅S
• 分子量: 707.681
• InChiKey: JOBOTZLNJPIOQH-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  47
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  208
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• [EN] BASIC NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM<br/>[FR] ANTAGONISTES DE BRADYKININE NON PEPTIDIQUE DE BASE ET COMPOSITIONS PHARMACEUTIQUES A BASE DESDITS ANTAGONISTES
  申请人：MENARINI RICERCHE SPA

  公开号：WO2003103671A1

  公开（公告）日：2003-12-18

  Non-peptide compounds of formula (I) having activity as specific antagonists of bradykinin (BK) B2 receptor. The compounds are chemically characterized by the presence of an alpha, alpha-disubstituted amino acid at least one amino group, free or salified, or the corresponding ammonium quaternary salt. These BK receptor antagonists are a novel class of medicaments which can be used in all the disorders in which said receptors are involved.

  化学式为(I)的非肽类化合物具有作为布雷金肽(BK) B2受体特异性拮抗剂的活性。这些化合物在化学上的特征是至少有一个氨基团存在α，α-二取代氨基酸，自由或盐化，或相应的铵季铵盐。这些BK受体拮抗剂是一类新型药物，可用于所有涉及该受体的疾病中。
• Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom
  申请人：Calvani Federico

  公开号：US20060205712A1

  公开（公告）日：2006-09-14

  Non-peptide compounds of formula (I) having activity as specific antagonists of bradykinin (BK) B2 receptor. The compounds are chemically characterized by the presence of an alpha, alpha-disubstituted amino acid at least one amino group, free or salified, or the corresponding ammonium quaternary salt. These BK receptor antagonists are a novel class of medicaments which can be used in all the disorders in which said receptors are involved

  具有缓激肽（BK）B2 受体特异性拮抗剂活性的式（I）非肽化合物。这些化合物的化学特征是含有至少一个α-α-二取代氨基酸基团（游离的或盐化的）或相应的季铵盐。这些 BK 受体拮抗剂是一类新型药物，可用于治疗所有涉及上述受体的疾病。
• BASIC NON-PEPTIDE BRADYKININ ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS THEREFROM
  申请人：Menarini Ricerche S.p.A.

  公开号：EP1513531A1

  公开（公告）日：2005-03-16
• US7491825B2
  申请人：——

  公开号：US7491825B2

  公开（公告）日：2009-02-17