N-(3-methoxypropyl)-2-methylprop-2-enamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(3-methoxypropyl)-2-methylprop-2-enamide
• 化学式: C₈H₁₅NO₂
• 分子量: 157.21
• InChiKey: IRMNYAOVVDEOKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20200353090A1

  公开（公告）日：2020-11-12

  The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, the polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.

  该发明涉及新型活性分子的前药。这些前药允许特别是将活性分子皮下或肌肉内注射，而这些活性分子的皮下或肌肉内注射由于在注射部位的毒性而具有问题或不可能，特别是由于在注射部位的毒性。根据本发明的前药包括一种活性成分，与一根聚合物链共价连接，优选为一种亲水性和/或热敏感性聚合物链。该发明特别涉及包括由丙烯酰胺单体或其衍生物之一至少部分形成的聚合物链的聚合物前药，该聚合物包括一个近端部分和一个末端部分；第一种药用活性分子共价结合到聚合物的近端部分；可能第二种药用活性分子共价结合到聚合物的末端部分。
• Acrylic sheet, acrylic adhesive sheet and process for preparing the sheets
  申请人：SOKEN CHEMICAL & ENGINEERING CO. LTD.,

  公开号：EP0696610A2

  公开（公告）日：1996-02-14

  The acrylic sheet of the invention is an acrylic sheet containing particles homogeneously dispersed in a resin matrix which does not substantially contain air bubbles and has an air bubble content of not more than 10 % by volume; in which the resin matrix for constituting the acrylic sheet is a crosslinked (meth)acrylic copolymer obtained by forming a crosslinked structure among the molecules of a (meth)acrylic copolymer, which is a copolymer of 0.1 - 15 % by weight of a polymerizable monomer having a functional group, 60 - 99.9 % by weight of a (meth)acrylic acid alkyl ester and 0 - 39.9 % by weight of other monomer and has a weight-average molecular weight of 150,000 to 1,200,000, by means of a polyfunctional compound having reactivity to the functional group of the polymerizable monomer for preparing the (meth)acrylic copolymer; and the particles dispersed in the resin matrix formed from the crosslinked (meth)acrylic copolymer have a mean particle diameter of 1 to 100 µm and a true specific gravity of 0.2 to 3.0. This acrylic sheet can be prepared by synthesizing a specific (meth)acrylic copolymer in an aqueous medium or an organic solvent, mixing a reaction solution of the copolymer with the polyfunctional compound and particles, casting the deformed mixture and drying it. The acrylic adhesive sheet of the invention is an adhesive sheet having an adhesive layer provided on at least one surface of the acrylic sheet, and can be prepared by forming the adhesive layer on the surface of the acrylic sheet.

  本发明的丙烯酸片材是一种丙烯酸片材，含有均匀分散在树脂基体中的颗粒，该树脂基体基本上不含气泡，气泡含量按体积计算不超过10%；其中，用于构成丙烯酸片材的树脂基体是一种交联（甲基）丙烯酸共聚物，该共聚物通过在（甲基）丙烯酸共聚物分子之间形成交联结构而获得，（甲基）丙烯酸共聚物是由0.1-15%（重量百分比）具有官能团的可聚合单体、60-99.9%（重量百分比）（甲基）丙烯酸烷基酯和0-39.9%（重量百分比）其他单体组成的共聚物，其重量平均分子量为150,000-1,200,000。9%（重量百分比）的(甲基)丙烯酸烷基酯和 0 - 39.9%（重量百分比）的其他单体的共聚物，其重量平均分子量为 150,000 - 1,200,000 ，通过与可聚合单体的官能团具有反应性的多官能化合物来制备(甲基)丙烯酸共聚物；分散在由交联的(甲基)丙烯酸共聚物形成的树脂基体中的颗粒的平均颗粒直径为 1 - 100 µm，真实比重为 0.2 - 3.0。这种丙烯酸胶片的制备方法是：在水介质或有机溶剂中合成特定的（甲基）丙烯酸共聚物，将共聚物的反应溶液与多官能团化合物和颗粒混合，浇注变形混合物并干燥。本发明的丙烯酸粘合剂片材是一种粘合剂片材，在丙烯酸片材的至少一个表面上设有粘合剂层，可通过在丙烯酸片材表面形成粘合剂层来制备。
• Method for vascular embolization and vascular embolizing agent
  申请人：JAPAN as represented by DIRECTOR GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：EP0704217A2

  公开（公告）日：1996-04-03

  A method for vascular embolization of a blood vessel of a patient comprises introducing a novel vascular embolizing agent which is an aqueous solution of a specific thermosensitive polymer, which is liquid at low temperatures but causes coagulation when heated to the body temperature of the patient, into the blood vessel followed by in situ heating of the solution. The thermosensitive polymer found to be suitable for the purpose is a homopolymer or copolymer of an N-substituted (meth)acrylamide monomer having a specified intrinsic viscosity in tetrahydrofuran and gives an aqueous solution capable of exhibiting phase transition from a liquid to a coagulate at a transition temperature of 10 to 37 °C.

  一种对病人血管进行栓塞的方法包括将一种新型血管栓塞剂导入血管，然后对溶液进行原位加热，这种新型血管栓塞剂是一种特定热敏聚合物的水溶液，在低温下呈液态，但加热到病人体温时会引起凝固。适用于这一目的的热敏性聚合物是一种 N-取代（甲基）丙烯酰胺单体的均聚物或共聚物，在四氢呋喃中具有特定的固有粘度，其水溶液能在 10 至 37 °C的转变温度下从液态转变为凝固体。
• Water-based ink for ink-jet, and ink jet recording method and instruments using the same
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0761782A1

  公开（公告）日：1997-03-12

  Disclosed herein is a water-based ink for ink-jet, comprising a liquid composition containing a coloring material and a liquid medium, wherein the ink comprises a polymer exhibiting a heat-reversible type thickening property and a compound having a light-heat converting function, or a polymer which exhibits a heat-reversible type thickening property and has a moiety capable of undergoing light-heat conversion.

  本文公开了一种用于喷墨的水基墨水，包括一种含有着色材料和液体介质的液体组合物，其中墨水包含一种具有热可逆型增稠特性的聚合物和一种具有光热转换功能的化合物，或一种具有热可逆型增稠特性并具有能够进行光热转换的分子的聚合物。
• EMULSION AND COATING LIQUID AND RECORDING MEDIUM USING THE SAME
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1380438A1

  公开（公告）日：2004-01-14

  The present invention discloses a polymer emulsion used for manufacturing a recording medium, characterized in comprising at least a polymer compound (A) which shows hydrophilicity at a temperature region not higher than a specific temperature (temperature-sensitive point), whereas lipophilicity in a temperature region above the temperature-sensitive point.

  本发明公开了一种用于制造记录介质的聚合物乳液，其特征在于至少包含一种聚合物化合物（A），该化合物在不高于特定温度（感温点）的温度区域显示亲水性，而在高于感温点的温度区域显示亲油性。