4-Thio-2'-desoxy-uridin-5'-phosphat | 50906-04-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: 4-Thio-2'-desoxy-uridin-5'-phosphat
• 英文别名: 4-thio-2'-deoxy-[5']uridylic acid；[(2R,3S,5R)-3-hydroxy-5-(2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
• CAS: 50906-04-2
• 化学式: C₉H₁₃N₂O₇PS
• 分子量: 324.251
• InChiKey: TZCXMOYDOSCPGG-SHYZEUOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• METHODS FOR INHIBITING/TREATING HIV INFECTIONS AND AIDS RELATED SYMPTOMS
  申请人：Therex Technologies, Inc.

  公开号：EP1248631A1

  公开（公告）日：2002-10-16
• Methods for inhibiting/treating hiv infections and aids related symptoms
  申请人：——

  公开号：US20030216334A1

  公开（公告）日：2003-11-20

  The present invention relates to a novel method for inhibiting the growth, elaboration and/or replication of HIV in human patients and to the prevention and treatment of human acquired immunodeficiency syndrome (AIDS) and other diseases caused by retroviral infection. In preferred aspects, the present invention provides a method for the use of a novel class of oligodeoxynucleotides consisting of 4-thio-2′-deoxyuridylate units for the prevention and treatment of both wild-type and drug-resistant Human Immunodeficiency Virus 1 (HIV), the causative pathogen of AIDS.
• [EN] METHODS FOR INHIBITING/TREATING HIV INFECTIONS AND AIDS RELATED SYMPTOMS<br/>[FR] METHODES D'INHIBITION/TRAITEMENT D'INFECTIONS PAR LE VIH ET DE SYMPTOMES LIES AU SIDA
  申请人：THEREX TECHNOLOGIES INC

  公开号：WO2001049297A1

  公开（公告）日：2001-07-12

  The present invention relates to a novel method for inhibiting the growth, elaboration and/or replication of HIV in human patients and to the prevention and treatment of human acquired immunodefiiciency syndrome (AIDS) and other diseases caused by retroviral infection. In preferred aspects, the present invention provides a method for the use of a novel class of oligodeoxynucleotides consisting of 4-thio-2'-deoxyuridylate units for the prevention and treatment of both wild-type and drug-resistant Human Immunodeficiency Virus 1 (HIV), the causative pathogen of AIDS.
• [EN] MONONUCLEOTIDES AND MONONUCLEOSIDES FOR USE IN THERAPY<br/>[FR] MONONUCLÉOTIDES ET MONONUCLÉOSIDES DESTINÉS À ÊTRE UTILISÉS EN THÉRAPIE
  申请人：UNIV DEBRECEN

  公开号：WO2007083173A2

  公开（公告）日：2007-07-26

  [EN] The present invention relates to thiolated pyrimidine-mononucleotides and pyrimidine- mononucleosides and their use as therapeutic agents. More closely, the present invention relates to therapeutic applications of 4-thio-uridine, its analogues, ribo- and deoxyribonucleotide derivatives and their various further derivatives, and also to these compounds for use in the therapeutic applications. Preferably, the subject of this invention is the use of these compounds and preparations containing these compounds as antiproliferative and/or antiviral agents.
  [FR] La présente invention concerne des pyrimidine-mononucléotides et des pyrimidine-mononucléosides thiolés et l'utilisation de ces derniers en tant qu'agents thérapeutiques. Plus spécifiquement, cette invention porte sur les applications thérapeutiques de la 4-thio-uridine, de ses analogues, des dérivés ribonucléotide et désoxyribonucléotide et de leurs divers autres dérivés ainsi que sur ces mêmes composés destinés à être utilisés dans des applications thérapeutiques. De préférence, le sujet de cette invention concerne l'utilisation de ces composés et de préparations contenant ces composés en tant qu'agents antiprolifératifs et/ou en tant qu'agents antiviraux.