H-DL-gGlu-DL-Cys(NO)-Gly-OEt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-DL-gGlu-DL-Cys(NO)-Gly-OEt
• 英文别名: 2-amino-5-[[1-[(2-ethoxy-2-oxoethyl)amino]-3-nitrososulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• 化学式: C₁₂H₂₀N₄O₇S
• 分子量: 364.38
• InChiKey: VAIKBJGYJPBUOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  203
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• sGC STIMULATORS
  申请人：Ironwood Pharmaceuticals, Inc.

  公开号：US20180065971A1

  公开（公告）日：2018-03-08

  The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I:

  本公开涉及可溶性鸟苷酸环化酶（sGC）的激动剂，包括它们的药物配方及其单独或与一个或多个额外药剂联合使用以治疗各种疾病，其中氮氧化物（NO）浓度增加、环鸟苷酸单磷酸（cGMP）浓度增加、或两者增加，或NO途径上调是可取的。这些化合物属于式I：
• [EN] 2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS<br/>[FR] PYRAZOLES 2-BENZYLE, 3-(PYRIMIDIN-2-YLE)-SUBSTITUÉS UTILES COMME STIMULATEURS DE SCG
  申请人：IRONWOOD PHARMACEUTICALS INC

  公开号：WO2013101830A1

  公开（公告）日：2013-07-04

  2-Benzyl, 3 - (pyrimidin- 2 -YL) substituted pyrazoles are described. They are useful as stimulators of sGC, particularly NO - independent, heme - dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

  描述了2-苄基，3-（嘧啶-2-基）取代的吡唑啉。它们可作为sGC的刺激剂，特别是NO-独立的、血红蛋白依赖的刺激剂。这些化合物可能对治疗、预防或管理本文披露的各种疾病有用。
• [EN] DEUTERATED SGC STIMULATORS<br/>[FR] STIMULATEURS DE SGC DEUTÉRÉS
  申请人：CYCLERION THERAPEUTICS INC

  公开号：WO2021195403A1

  公开（公告）日：2021-09-30

  The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine onophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I: or a pharmaceutically acceptable salt thereof, wherein each of Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8 and Y9 is independently selected from hydrogen and deuterium, as well as pharmaceutical compositions, methods and uses thereof.

  本公开涉及可溶性鸟苷酸环化酶（sGC）的激动剂，包含它们的药物配方及其单独或与一个或多个额外药剂组合使用以治疗各种疾病，其中增加一氧化氮（NO）浓度或增加环鸟苷酸单磷酸（cGMP）浓度，或两者，或上调NO途径是可取的。化合物为Formula I:或其药用盐，其中Y1、Y2、Y3、Y4、Y5、Y6、Y7、Y8和Y9中的每一个可独立选择自氢和氘，以及其药用组合物、方法和用途。
• [EN] SGC STIMULATORS<br/>[FR] STIMULATEURS DE LA SGC
  申请人：IRONWOOD PHARMACEUTICALS INC

  公开号：WO2014047111A1

  公开（公告）日：2014-03-27

  Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

  描述了式I的化合物。它们可作为sGC的刺激剂，特别是独立于NO的、依赖血红素的刺激剂。这些化合物可能对治疗、预防或管理本文中披露的各种疾病有用。
• NONOATE DERIVATIVES AND USES THEREOF
  申请人：IRONWOOD PHARMACEUTICALS

  公开号：US20140135295A1

  公开（公告）日：2014-05-15

  A compound of Formula (I): or a pharmaceutically acceptable salt of the compound. Also described are pharmaceutical formulations thereof and methods of using the same.

  化合物的化学式（I）：或者该化合物的药用可接受的盐。还描述了其药物制剂和使用方法。