2-Oxo-2-((1-phenylethyl)amino)ethyl 2-(naphtho[2,1-b]furan-1-yl)acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 2-Oxo-2-((1-phenylethyl)amino)ethyl 2-(naphtho[2,1-b]furan-1-yl)acetate
• 英文别名: [2-oxo-2-(1-phenylethylamino)ethyl] 2-benzo[e][1]benzofuran-1-ylacetate
• 化学式: C₂₄H₂₁NO₄
• 分子量: 387.4
• InChiKey: WKXVPBNNNWFVTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHODS AND COMPOSITIONS FOR INHIBITING GRAM POSITIVE BACTERIA
  申请人：The University of Chicago

  公开号：US20150246024A1

  公开（公告）日：2015-09-03

  Methods and compositions are provided for treating or preventing a Gram-positive bacteria infection using an inhibitor of lipo-teichoic acid synthase (LtaS). In some embodiments, the inhibitor is a small molecule. In certain embodiments, the inhibitor is 2-oxo-2-(5-phenyl-1,3,4-oxadiazol-2-ylamino)ethyl 2-naphtho[2,1-b]furan-1 -ylacetate, or a salt thereof.
• [EN] INHIBITING GRAM POSITIVE BACTERIA<br/>[FR] INHIBITION DE BACTÉRIES À GRAM POSITIF
  申请人：UNIV CHICAGO

  公开号：WO2014031681A1

  公开（公告）日：2014-02-27

  Methods and compositions are provided for treating or preventing a Gram-positive bacteria infection using an inhibitor of lipoteichoic acid synthase (LtaS). In some embodiments, the inhibitor is a small molecule. In certain embodiments, the inhibitor is 2- oxo-2-(5- phenyl- 1, 3, 4-oxadiazol-2-ylamino)ethyl 2-naphtho[2,l-b]furan-l-ylacetate, or a salt thereof.