1,2,4,5-四甲基-3-[(2,3,5,6-四甲基苯基)甲基]苯 | 6970-00-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,2,4,5-四甲基-3-[(2,3,5,6-四甲基苯基)甲基]苯
• 英文名称: bis(2,3,5,6-tetramethylphenyl)methane
• 英文别名: 2,2',3,3',5,5',6,6'-Octamethyl-diphenylmethan；1,1'-Methylenebis(2,3,5,6-tetramethylbenzene)；1,2,4,5-tetramethyl-3-[(2,3,5,6-tetramethylphenyl)methyl]benzene
• CAS: 6970-00-9
• 化学式: C₂₁H₂₈
• 分子量: 280.453
• InChiKey: WMMIAXPRAGKYLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2902909090

反应信息

• 作为反应物：
  描述：

  1,1-二氯甲醚 、 1,2,4,5-四甲基-3-[(2,3,5,6-四甲基苯基)甲基]苯 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 以78%的产率得到didurylmethane-4,4'-dicarbaldehyde
  参考文献：
  名称：

  Synthesis of sterically hindered aromatic dialdehydes

  摘要：

  A study was carried out on the formylation of a series of aromatic compounds containing two mesitylene or durene residues [dimesityl (I), dimesitylmethane (II), 1,2-dimesitylethane (III), 1,6-dimesitylhexane (IV), dimesityl sulfide (V), 1,1-dimesitylethylene (VI), 1,1-dimesityl-1-butene (VII), and didurylmethane (VIII)) by the action of dichloromethyl methyl ether (DCM) in the presence of AlCl3 and TiCl4. The corresponding dialdehydes are the major products. The formylation products when the reaction is carried out in the presence of AlCl3 in the case of (I) and (V) contain significant amounts of monoaldehydes, while partial cleavage of the substrates with the formation of products containing only one benzene ring is observed in the case of (II) and (VIII) in addition to formylation.

  DOI：

  10.1007/bf00961271
• 作为产物：
  描述：

  三聚甲醛 、 1,2,4,5-四甲苯 在 indium(III) chloride 作用下， 以46%的产率得到1,2,4,5-四甲基-3-[(2,3,5,6-四甲基苯基)甲基]苯
  参考文献：
  名称：

  An efficient synthesis of diarylmethanes via InCl3·4H2O-catalyzed dehydration of electron-rich arenes with trioxane

  摘要：

  A facile, efficient and environmentally benign procedure for the synthesis of diarylmethanes via the reaction of arenes with trioxane catalyzed by InCl3 center dot 4H(2)O was developed. The reactions of aromatic compounds bearing electron-donating group proceeded smoothly affording the corresponding diarylmethanes in good to excellent yields. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.02.020

文献信息

• Sc(OTf)₃-Catalyzed Synthesis of Symmetrical Dithioacetals and Bisarylmethanes Using Nitromethane as a Methylene Source
  作者：Dattatraya H. Dethe、Manmohan Shukla、Balu D. Dherange

  DOI：10.1021/acs.orglett.0c01831

  日期：2020.8.7

  Use of nitromethane as an electrophilic methylene source for the synthesis of symmetrical dithioacetals and bisarylmethanes has been showcased using Sc(OTf)(3) as a catalyst. The procedure allows straightforward access to the densely functionalized dithioacetals and bisarylmethanes under mild conditions. Additionally, the method has been applied for the synthesis of antimalarial tetramethyl mellotojaponin C and anticancer dimeric phloroglucinol derivative.
• The Arylmethylation of Benzene Derivatives
  作者：Clark M. Welch、Hilton A. Smith

  DOI：10.1021/ja01153a104

  日期：1951.9
• Lapkin, Zhurnal Obshchei Khimii, 1946, vol. 16, p. 729,732,733
  作者：Lapkin

  DOI：——

  日期：——
• Nyberg,K., Acta Chemica Scandinavica (1947), 1970, vol. 24, p. 1609 - 1617
  作者：Nyberg,K.

  DOI：——

  日期：——
• YAKUBOV, A. P.;TSYGANOV, D. V.;BELENKIJ, L. I.;KRAYUSHKIN, M. M., IZV. AN CCCP. CEP. XIM.,(1991) N, S. 1700-1703
  作者：YAKUBOV, A. P.、TSYGANOV, D. V.、BELENKIJ, L. I.、KRAYUSHKIN, M. M.

  DOI：——

  日期：——