1,2,4-三甲基-4H-咪唑-5-酮 | 32023-93-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,2,4-三甲基-4H-咪唑-5-酮
• 英文名称: 2,3,5-trimethyl-3,5-dihydro-imidazol-4-one
• 英文别名: 1,2,4-Trimethylimidazolin-5-on；Trimethyl-1,2,4-imidazolinon-5；2,3,5-Trimethyl-3,5-dihydro-4H-imidazol-4-one；1,2,4-trimethyl-4H-imidazol-5-one
• CAS: 32023-93-1
• 化学式: C₆H₁₀N₂O
• 分子量: 126.158
• InChiKey: WFXDHDDBCTZAED-UHFFFAOYSA-N

物化性质

• 沸点：
  163.8±23.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2,4-三甲基-4H-咪唑-5-酮 生成 d,l-Di(1,2,4-trimethylimdazolin-5-on)
  参考文献：
  名称：

  MAQUESTIAN A.; VAN HAVERBEKE Y.; FLAMMANG-BARBIEUX M.; BEAUBAYS-BAR F.; D+, BULL. SOC. CHIM. BELG., 1976, 85, NO 8, 573-577

  摘要：

  DOI：
• 作为产物：
  描述：

  2-amino-N-methylpropanamide 、 原乙酸三乙酯 反应 3.0h， 以56%的产率得到1,2,4-三甲基-4H-咪唑-5-酮
  参考文献：
  名称：

  A Concise and Selective Synthesis of Novel 5-Aryloxyimidazole NNRTIs

  摘要：

  A concise and efficient route to the construction of a 5-aryloxyimidazole has been developed. The key step was the selective O-arylation of a 2,4-dimethoxybenzyl-protected imidazolone. The final compound is a potent inhibitor of HIV reverse transcriptase.

  DOI：

  10.1021/ol060316x

文献信息

• METHOD FOR THE DETECTION OF PREDIABETES
  申请人：Watanabe Toshiaki

  公开号：US20130004972A1

  公开（公告）日：2013-01-03

  Provided is a method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay, with which it is possible to treat many samples as simply and as safely as with blood sugar assay, and to collect a blood sample taken during a primary health screening in one procedure without imposing any time restraints, complications or risks on the subject. The method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay comprises assaying the methylglyoxal-modified arginine derivative in blood using an assay system which employs an antibody that specifically recognizes methylglyoxal-modified arginine derivative.
• A Concise and Selective Synthesis of Novel 5-Aryloxyimidazole NNRTIs
  作者：Lyn H. Jones、Thomas Dupont、Charles E. Mowbray、Sandra D. Newman

  DOI：10.1021/ol060316x

  日期：2006.4.1

  A concise and efficient route to the construction of a 5-aryloxyimidazole has been developed. The key step was the selective O-arylation of a 2,4-dimethoxybenzyl-protected imidazolone. The final compound is a potent inhibitor of HIV reverse transcriptase.
• MAQUESTIAN A.; VAN HAVERBEKE Y.; FLAMMANG-BARBIEUX M.; BEAUBAYS-BAR F.; D+, BULL. SOC. CHIM. BELG., 1976, 85, NO 8, 573-577
  作者：MAQUESTIAN A.、 VAN HAVERBEKE Y.、 FLAMMANG-BARBIEUX M.、 BEAUBAYS-BAR F.、 D+

  DOI：——

  日期：——