1,2-二棕榈酰-SN-甘油-3-二氧磷基-(N-甲基)-乙醇胺 | 3930-13-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 中文名称: 1,2-二棕榈酰-SN-甘油-3-二氧磷基-(N-甲基)-乙醇胺
• 中文别名: 1,2-二棕榈酰-sn-glycero-3-磷-(n-甲基)-乙醇胺
• 英文名称: L-1,2-Di-O-palmitoyl-glycerin-3-phosphorsaeure-(2-methylamino-ethylester)
• 英文别名: 16:0 Monomethyl PE；[(2R)-2,3-di(hexadecanoyloxy)propyl] 2-(methylazaniumyl)ethyl phosphate
• CAS: 3930-13-0
• 化学式: C₃₈H₇₆NO₈P
• mdl: MFCD00042875
• 分子量: 705.997
• InChiKey: QSBINWBNXWAVAK-PSXMRANNSA-N

物化性质

• 物理描述：
  Solid
• 稳定性/保质期：

  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  10.8
• 重原子数：
  48
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.947
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  9

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3

制备方法与用途

制备方法
用作化学试剂

用途简介

用途
用作化学试剂

反应信息

• 作为产物：
  描述：

  1,2-二棕榈酰-sn-丙三醇 在 水 、 dinitrogen tetraoxide 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 5.17h， 生成 1,2-二棕榈酰-SN-甘油-3-二氧磷基-(N-甲基)-乙醇胺
  参考文献：
  名称：

  McGuigan, Christopher; Anson, Michael S.; Swords, Bernadette, Journal of the Chemical Society. Perkin transactions I, 1992, # 16, p. 2075 - 2078

  摘要：

  DOI：

文献信息

• The synthesis of phospholipids. Part I. Phosphatidyl and lysophosphatidyl ethanolamines
  作者：J. D. Billimoria、K. O. Lewis

  DOI：10.1039/j39680001404

  日期：——

  A synthesis of saturated and unsaturated optically active phosphatidyl and lysophosphatidyl ethanolamines is described in which the triphenylmethyl group is used for protection. Mild conditions are described for the removal of this group to give the required phospholipids in high yield. Two routes are described, one which allows ready modification of the fatty acid structure and the other which is

  描述了饱和和不饱和光学活性的磷脂酰和溶血磷脂酰乙醇胺的合成，其中三苯甲基用于保护。描述了温和的条件以除去该基团，从而以高收率获得所需的磷脂。描述了两种途径，一种途径允许容易地修饰脂肪酸结构，另一种途径在引入乙醇胺部分的修饰时更有用。
• Functional associative coatings for nanoparticles
  申请人：Hainfeld James F.

  公开号：US20080089836A1

  公开（公告）日：2008-04-17

  Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

  本文描述了一种纳米颗粒，其表面涂覆有由表面结合分子和两亲分子形成的双层分子层。该双层涂层可以自组装在纳米颗粒上，使用易得的材料/分子。双层涂层纳米颗粒的模块化设计提供了一种方便和高效地优化其性质的方法。此外，本文还描述了这种纳米颗粒在医学、实验室技术、工业和商业应用中的用途。
• Phospholipid-analogous compounds
  申请人：——

  公开号：US20030198663A1

  公开（公告）日：2003-10-23

  Phospholipid-analogous compounds of the general formula (I) 1 in which A 2 where R 1 and R 2 are, independently of one another, hydrogen, a saturated or unsaturated acyl or alkyl radical which can optionally be branched or/and substituted, where the total of the carbon atoms in the acyl and alkyl is 16 to 44 C atoms, s is an integer from 0 to 8, c is a radical of a primary or secondary alcohol of the formula RO—, where R is a saturated or unsaturated alkyl radical, mainly with cis double bond, of from 12 to 30 carbon atoms, n is an integer from 2 to 8, R 3 a can be 1,2-dihydroxypropyl or b can be alkyl with 1 to 3 C atoms when z is >0 or c can be alkyl with 1 to 3 carbon atoms when n≠2 and z=0, m is 1 or 2, x is an integer from 0 to 8, y is 1 for z=1 to 5 or is 1 to 4 for z=1 z is an integer from 0 to 5, are novel and are suitable as liposome constituents, solubilizers and pharmaceuticals.

  通式（I）的类磷脂类似化合物，其中A是一个基团，R1和R2独立地是氢、饱和或不饱和的酰基或烷基基团，可以是支链的和/或取代的，酰基和烷基中的碳原子总数为16到44个，s是从0到8的整数，c是具有RO—式的一级或二级醇基团，其中R是饱和或不饱和的烷基基团，主要带有顺式双键，碳原子数为12到30个，n是从2到8的整数，R3a可以是1,2-二羟基丙基或者当z>0时可以是碳原子数为1到3的烷基，或者当n≠2且z=0时可以是碳原子数为1到3的烷基，m为1或2，x是从0到8的整数，y对于z=1到5时为1，对于z=1时为1到4，z是从0到5的整数。这些化合物是新颖的，适用于脂质体成分、溶剂和药物。
• PHOSPHOLIPID-ANALOGOUS COMPOUNDS
  申请人：EIBL Hans-Jörg

  公开号：US20100183705A1

  公开（公告）日：2010-07-22

  Phospholipid-analogous compounds of the general formula (I) in which A where R 1 and R 2 are, independently of one another, hydrogen, a saturated or unsaturated acyl or alkyl radical which can optionally be branched or/and substituted, where the total of the carbon atoms in the acyl and alkyl is 16 to 44 C atoms, s is an integer from 0 to 8, c is a radical of a primary or secondary alcohol of the formula RO—, where R is a saturated or unsaturated alkyl radical, mainly with cis double bond, of from 12 to 30 carbon atoms, n is an integer from 2 to 8, R 3 a can be 1,2-dihydroxypropyl or b can be alkyl with 1 to 3 C atoms when z is >0 or c can be alkyl with 1 to 3 carbon atoms when n≠2 and z=0, m is 1 or 2, x is an integer from 0 to 8, y is 1 for z=1 to S′ or is 1 to 4 for z=1 z is an integer from 0 to 5, are novel and are suitable as liposome constituents, solubilizers and pharmaceuticals.

  通式（I）的类磷脂衍生物，其中A是，R1和R2分别是氢，饱和或不饱和的脂肪酰基或烷基，可以选择支链或/和取代，其中酰基和烷基中的碳原子总数为16到44个碳原子，s是0到8的整数，c是RO—的主要为顺式双键的一级或二级醇的基团，其中R是饱和或不饱和的烷基基团，其碳原子数为12到30个，n是2到8的整数，R3a可以是1,2-二羟基丙基或当z>0时可以是1到3个C原子的烷基，或当n≠2且z=0时可以是1到3个碳原子的烷基，m为1或2，x是0到8的整数，y为z=1到S'时为1或z=1z时为1到4，z是0到5的整数，这些化合物是新的，并适用于作为脂质体成分，溶解剂和药物。
• PHOSPHOLIPIDANALOGE VERBINDUNGEN
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP1019417B1

  公开（公告）日：2002-10-16