申请人:Hovione Scientia Limited
公开号:US20220002226A1
公开(公告)日:2022-01-06
An amorphous form of a chelating agent is provided, in particular wherein the chelating agent comprises ethylenediaminetetraacetic acid/edetic acid (EDTA), diethylenetriaminepentaacetic acid/pentetic acid (DTPA), nitrilotriacetic acid (NTA), amino tris(methylenephosphonic acid) (ATMP), ethylenediamine tetramethylene phosphonic acid (EDTMP), 1-hydroxyethane 1,1-diphosphonic acid (HEDP), ethylenediaminedisuccinic acid (EDDS), iminodisuccinic acid (IDS), hydroxamic acid, oxalic acid, galactaric acid, metaphosphoric acid, or phytic acid, or a salt of any one or more of the above acids, or a mixture of two or more of any of the above acids or salts thereof.
A process for preparing an amorphous form of a chelating agent comprises the steps of:
a) Dissolving the chelating agent in a suitable solvent;
b) Optionally purifying the solution;
c) Isolating an amorphous form of the chelating agent;
d) Optionally post drying or conditioning the amorphous form of the chelating agent.