戊二酸铵 | 29750-34-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 戊二酸铵
• 英文名称: Ammonium hydrogen glutarate
• 英文别名: Azanium;hydron;pentanedioate；azanium;hydron;pentanedioate
• CAS: 29750-34-3
• 化学式: C₅H₈O₄*H₃N
• 分子量: 149.147
• InChiKey: GKGYMXPRDRXIIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.63
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  78.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  戊二腈 反应 4.0h， 以7.7%的产率得到戊二酸铵
  参考文献：
  名称：

  Chemoenzymic Production of Lactams from Aliphatic α,ω-Dinitriles

  摘要：

  Five- and six-membered ring lactams have been prepared by first converting an aliphatic alpha,omega-dinitrile to an omega-cyanocarboxylic acid ammonium salt, using a microbial cell catalyst having an aliphatic nitrilase activity (Acidovorax: facilis 72W, ATCC 55746) or a combination of nitrile hydratase and amidase activities (Comamonas testosteroni 5-MGAM-4D, ATCC 55744). The omega-cyanocarboxylic acid ammonium salt was then directly converted to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate omega-cyanocarboxylic acid or omega-aminocarboxylic acid. Only one of two possible lactam products was produced from alpha-alkyl-substituted alpha,omega-dinitriles, where the nitrilase of A. facilis 72W regioselectively hydrolyzed only the omega-cyano group to produce a single cyanocarboxylic acid ammonium salt in greater than 98% yield.

  DOI：

  10.1021/jo9804386

文献信息

• TUXTAEV, S.;NARXODZHAEV, A. X.;ASKAROVA, F. S.;ISHCHANXODZHAEV, S. S., 14 MENDELEEV. SEZD PO OBSHCH. I PRIKL. XIMII, M.,(1989) S. 370
  作者：TUXTAEV, S.、NARXODZHAEV, A. X.、ASKAROVA, F. S.、ISHCHANXODZHAEV, S. S.

  DOI：——

  日期：——
• Chemoenzymic Production of Lactams from Aliphatic α,ω-Dinitriles
  作者：John E. Gavagan、Susan K. Fager、Robert D. Fallon、Patrick W. Folsom、Frank E. Herkes、Amy Eisenberg、Eugenia C. Hann、Robert DiCosimo

  DOI：10.1021/jo9804386

  日期：1998.7.1

  Five- and six-membered ring lactams have been prepared by first converting an aliphatic alpha,omega-dinitrile to an omega-cyanocarboxylic acid ammonium salt, using a microbial cell catalyst having an aliphatic nitrilase activity (Acidovorax: facilis 72W, ATCC 55746) or a combination of nitrile hydratase and amidase activities (Comamonas testosteroni 5-MGAM-4D, ATCC 55744). The omega-cyanocarboxylic acid ammonium salt was then directly converted to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate omega-cyanocarboxylic acid or omega-aminocarboxylic acid. Only one of two possible lactam products was produced from alpha-alkyl-substituted alpha,omega-dinitriles, where the nitrilase of A. facilis 72W regioselectively hydrolyzed only the omega-cyano group to produce a single cyanocarboxylic acid ammonium salt in greater than 98% yield.