5-methyl-2H-pyrazole-3,4-dione 4-[(2-methoxy-phenyl)-hydrazone] | 65078-62-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-methyl-2H-pyrazole-3,4-dione 4-[(2-methoxy-phenyl)-hydrazone]
• 英文别名: 4-[2-(2-methoxyphenyl)hydrazinyl]-5-methylpyrazol-3-one
• CAS: 65078-62-8
• 化学式: C₁₁H₁₂N₄O₂
• 分子量: 232.242
• InChiKey: UPBPQRJQBBFHFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  75.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-methyl-2H-pyrazole-3,4-dione 4-[(2-methoxy-phenyl)-hydrazone] 、 硫酸二甲酯 以60%的产率得到
  参考文献：
  名称：

  AMER F. A.; HARHASH A. E.-H.; METWALLY M. A., Z. NATURFORSCH. , 1977, 32B, NO 8, 943-947

  摘要：

  DOI：

文献信息

• PYRAZOL-3-ONES THAT ACTIVATE PRO-APOTOTIC BAX
  申请人：Dana Farber Cancer Institute, Inc.

  公开号：EP3799871A2

  公开（公告）日：2021-04-07

  This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).

  本申请的特点是吡唑-3-酮化合物能激活促细胞凋亡的 BAX。此外，还介绍了使用此类化合物的方法，例如，用于治疗或预防与细胞凋亡失调（例如，病变或受损细胞凋亡不足或病变或受损细胞基本上没有凋亡）有关的疾病、失调和病症。
• Pyrazol-3-ones that activate pro-apoptotic BAX
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US11358960B2

  公开（公告）日：2022-06-14

  This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).

  本申请的特点是吡唑-3-酮化合物能激活促细胞凋亡的 BAX。此外，还介绍了使用此类化合物的方法，例如，用于治疗或预防与细胞凋亡失调（例如，病变或受损细胞凋亡不足或病变或受损细胞基本上没有凋亡）有关的疾病、失调和病症。
• EP2766355B1
  申请人：——

  公开号：EP2766355B1

  公开（公告）日：2020-12-23
• HYDROCARBON SYNTHESIS METHODS, APPARATUS, AND SYSTEMS
  申请人：SarTec Corporation

  公开号：US20140046104A1

  公开（公告）日：2014-02-13

  Embodiments of the invention include apparatus and systems for hydrocarbon synthesis and methods regarding the same. In an embodiment, the invention includes a process for creating a hydrocarbon product stream comprising reacting a reaction mixture in the presence of a catalyst inside of a reaction vessel to form a product mixture, the reaction mixture comprising a carbon source and water. The temperature inside the reaction vessel can be between 450 degrees Celsius and 600 degrees Celsius and the pressure inside the reaction vessel can be above supercritical pressure for water. In an embodiment, the invention includes an extrusion reactor system for creating a hydrocarbon product stream. The temperature inside the extrusion reactor housing between 450 degrees Celsius and 600 degrees Celsius. Pressure inside the reaction vessel can be above supercritical pressure for water. Other embodiments are also included herein.
• PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20210032234A1

  公开（公告）日：2021-02-04

  This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment or prevention of diseases, disorders, and conditions associated with deregulated apoptosis of cells (e.g., insufficient apoptosis of diseased or damaged cells or essentially the absence of apoptosis of diseased or damaged cells).