2-(4-Amino-2,6-dimethylphenoxy)-1-(pyrrolidin-1-yl)ethanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-Amino-2,6-dimethylphenoxy)-1-(pyrrolidin-1-yl)ethanone
• 英文别名: 2-(4-amino-2,6-dimethylphenoxy)-1-pyrrolidin-1-ylethanone
• 化学式: C₁₄H₂₀N₂O₂
• mdl: MFCD07658186
• 分子量: 248.325
• InChiKey: FPRFYNSOGLCVTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 2-(4-Amino-2,6-dimethylphenoxy)-1-(pyrrolidin-1-yl)ethanone 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors

  摘要：

  A series of pyrazolylpyrimidine scaffold based Syk inhibitors were synthesized and evaluated for their biological activities and selectivity. Lead optimization efforts provided compounds with potent Syk inhibition in both enzymatic and TNF-a release assay. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.09.011

文献信息

• Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors
  作者：Jang-Sik Choi、Hae-jun Hwang、Se-Won Kim、Byung Il Lee、Jaekyoo Lee、Ho-Juhn Song、Jong Sung Koh、Jung-Ho Kim、Phil Ho Lee

  DOI：10.1016/j.bmcl.2015.09.011

  日期：2015.10

  A series of pyrazolylpyrimidine scaffold based Syk inhibitors were synthesized and evaluated for their biological activities and selectivity. Lead optimization efforts provided compounds with potent Syk inhibition in both enzymatic and TNF-a release assay. (C) 2015 Elsevier Ltd. All rights reserved.