戊基D-葡糖苷 | 100231-63-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 戊基D-葡糖苷
• 英文名称: n-amyl D-glucopyranoside
• 英文别名: amyl glucoside；Glu-C5；Pentyl D-glucoside；(2R,3S,4S,5R)-2-(hydroxymethyl)-6-pentoxyoxane-3,4,5-triol
• CAS: 100231-63-8
• 化学式: C₁₁H₂₂O₆
• 分子量: 250.292
• InChiKey: RYIWDDCNJPSPRA-YBTJCZCISA-N

物化性质

• 沸点：
  252℃[at 101 325 Pa]
• 密度：
  1.2[at 20℃]
• LogP：
  -0.54 at 20℃

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  D-葡萄糖 、 戊醇 以65%的产率得到戊基D-葡糖苷
  参考文献：
  名称：

  Medicament comprising a reducing alkyl-sugar monomer for the treatment of inflammatory disorders

  摘要：

  该发明涉及一种药物，包括至少一种含有羟基功能的还原烷基糖单体，该羟基功能在C2-C40处被烷氧基取代，所述药物通常用于调节炎症机制。还原糖通常选自包含鼠李糖、岩藻糖和葡萄糖的组。该发明还涉及一种化妆品处理方法，涉及局部应用包含至少一种含有羟基功能的还原烷基糖单体，该羟基功能在C2-C40处被烷氧基取代的组合物。

  公开号：

  US20070134187A1

文献信息

• ARYL GLYCOSIDE COMPOUND, PREPARATION METHOD AND USE THEREOF
  申请人：Xu Zusheng

  公开号：US20130324464A1

  公开（公告）日：2013-12-05

  Disclosed are an aryl glycoside compound as represented by formula I or formular I′, a pharmaceutically acceptable salt thereof, optical isomer thereof or a prodrug thereof. The present invention relates to a method of preparing said aryl glycoside compound and the use thereof The aryl glycoside compound of the present invention has an excellent ability on inhibit SGLT activity, especially SGLT2 activity, and is diabetes-fighting medicine with great potential.

  公开了一种由化学式I或化学式I'表示的芳基糖苷化合物，其药学上可接受的盐，其光学异构体或其前药。本发明涉及一种制备所述芳基糖苷化合物的方法及其用途。本发明的芳基糖苷化合物具有出色的抑制SGLT活性，特别是SGLT2活性的能力，是具有巨大潜力的抗糖尿病药物。
• Branched Polymeric Emulsifiers
  申请人：Lubrizol Advanced Materials, Inc.

  公开号：US20150218312A1

  公开（公告）日：2015-08-06

  The present invention relates to esterified glycerylated alkyl glycoside and to a process for making same. The esterified glycerylated alkyl glycoside have one or more polyglyceryl moieties and one or more acyl moieties, wherein all of the one or more acyl moieties are situated on the one or more polyglyceryl moieties via an ester linkage. These compounds have been found to be useful as emulsifiers and coemulsifiers in the formulation of a phase stable emulsions suitable for use in personal care, home care, industrial and institutional, and health care applications.

  本发明涉及酯化的甘油化烷基葡糖苷以及制备该化合物的方法。所述的酯化的甘油化烷基葡糖苷具有一个或多个聚甘油基团和一个或多个酰基团，其中所有的一个或多个酰基团通过酯键位于一个或多个聚甘油基团上。已发现这些化合物在制备适用于个人护理、家庭护理、工业和机构、以及医疗保健应用的相稳定乳化剂和共乳化剂方面具有实用性。
• High level production of p-hydroxybenzoic acid in green plants
  申请人：——

  公开号：US20020002715A1

  公开（公告）日：2002-01-03

  The invention relates to high-level production of pHBA in green plants using a unique expression cassette. The latter comprises a chorismate pyruvate lyase (CPL) coding sequence operably linked to a suitable promoter capable of driving protein expression in higher plants. Additionally, the CPL cassette comprises a sequence encoding a chloroplast transit peptide, its natural cleavage site, and a small portion of the transit peptide donor protein fused to the N-terminus of CPL. The chloroplast targeting sequence targets the foreign protein to the chloroplast compartment and aids in its uptake into the organelle. The cleavage site is unique to the transit peptide, and cleavage of the chimeric protein encoded by the cassette at this site releases a novel polypeptide that has full enzyme activity, comprising the mature CPL enzyme and a small portion of the transit peptide donor.

  本发明涉及使用独特的表达盒在绿色植物中高水平生产pHBA。该表达盒包括一个编码脱氧香豆酸-丙酮酸裂解酶（CPL）的序列，与能够在高等植物中驱动蛋白质表达的适当启动子可操作地连接。此外，CPL表达盒包括一个编码叶绿体转运肽的序列，其天然裂解位点和一小部分转运肽供体蛋白与CPL的N-端融合。叶绿体定位序列将外源蛋白定位到叶绿体区域并有助于其进入细胞器。裂解位点是转运肽唯一的，该盒编码的嵌合蛋白在该位点的裂解释放出一个全酶活性的新型多肽，包括成熟的CPL酶和一小部分的转运肽供体。
• Alkyl Glycoside-Based Micellar Thickeners For Surfactant Systems
  申请人：LUBRIZOL ADVANCED MATERIALS, INC.

  公开号：US20160022557A1

  公开（公告）日：2016-01-28

  A rheology modifier which includes a mixture of short and long chain fatty acid esters is suitable for use in liquid surfactant-based compositions. A surfactant-based composition includes a surfactant, the rheology modifier, and water. The rheology modifier includes a mixture of alkyl glycoside fatty acid esters including a long chain fatty acid ester of an alkyl glycoside and a short chain fatty acid ester of an alkyl glycoside. The long chain fatty acid ester includes at least one fatty acid residue: R 1 (O)O—, wherein R 1 is a C 12 or higher hydrocarbon. The short chain fatty acid ester includes least one fatty acid residue: R 2 (O)O—, wherein R 2 is a C 6 -C 10 hydrocarbon.

  一种流变改性剂，包括短链和长链脂肪酸酯的混合物，适用于液体表面活性剂基组成物中的使用。表面活性剂基组成物包括表面活性剂、流变改性剂和水。流变改性剂包括烷基糖苷脂肪酸酯的混合物，包括烷基糖苷的长链脂肪酸酯和烷基糖苷的短链脂肪酸酯。长链脂肪酸酯包括至少一个脂肪酸残基：R1（O）O-，其中R1是C12或更高碳氢化合物。短链脂肪酸酯包括至少一个脂肪酸残基：R2（O）O-，其中R2是C6-C10碳氢化合物。
• Methods and compositions for synthesis of oligosacccharides using mutant glycosidase enzymes
  申请人：UNIVERSITY OF BRITISH COLUMBIA

  公开号：EP1211320A2

  公开（公告）日：2002-06-05

  Mutant glycosidase enzymes are formed in which the normal nucleophilic amino acid within the active site has been changed to a non-nucleophilic amino acid. These enzymes cannot hydrolyze disaccharide products, but can still form them. Using this enzyme, oligoeaccharides are synthesized by preparing a mixture of an α-glycosol fluoride and a glycoside acceptor molecule; enzymatically coupling the α-glycosol fluoride to the glycoside acceptor molecule to form a glycosol glycoside product using the mutant glycosidase enzyme; and recovering the glycosyl product. The enzymes to be used are mutant forms of human or porcine α-amylase or yeast α-glucosidose having two catalytically active amino acids with carboxylic acid side claims within the active site, in the wild-type enzyme, with one of these amino acids being replaced by a different amino acid.

  突变糖苷酶的活性位点内的正常亲核氨基酸已变为非亲核氨基酸。这些酶不能水解双糖产物，但仍能形成双糖产物。使用这种酶合成低聚糖的方法是：制备α-糖醇氟化物和糖苷受体分子的混合物；使用突变糖苷酶将α-糖醇氟化物与糖苷受体分子进行酶偶联，形成糖醇糖苷产物；然后回收糖基产物。要使用的酶是人或猪α-淀粉酶或酵母α-糖苷酶的突变体形式，在野生型酶的活性位点内有两个具有羧酸侧要求的催化活性氨基酸，其中一个氨基酸被不同的氨基酸取代。