5-{[2-(3-{3-[({[({[5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido}propanamido)ethyl]sulfanyl}-5-oxopent-3-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-{[2-(3-{3-[({[({[5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido}propanamido)ethyl]sulfanyl}-5-oxopent-3-enoic acid
• 英文别名: (E)-5-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-5-oxopent-3-enoic acid
• 化学式: C₂₆H₄₀N₇O₁₉P₃S
• 分子量: 879.6
• InChiKey: URTLOTISFJPPOU-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.7
• 重原子数：
  56
• 可旋转键数：
  23
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  426
• 氢给体数：
  10
• 氢受体数：
  24

文献信息

• BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS
  申请人：INVISTA TECHNOLOGIES S.a.r.l.

  公开号：US20150337275A1

  公开（公告）日：2015-11-26

  Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.

  本发明实施例涉及在分离酶存在或在表达这些酶的重组宿主细胞存在下，生物合成双或三功能C7烷的方法。这些双或三功能C7烷在生产尼龙-7、尼龙-7，x、尼龙-x，7和聚酯中作为中间体是有用的。
• METHOD FOR N-BUTANOL PRODUCTION USING HETEROLOGOUS EXPRESSION OF ANAEROBIC PATHWAYS
  申请人：SilicoLife Lda.

  公开号：EP3775245A1

  公开（公告）日：2021-02-17
• Pathway Analysis of Cell Culture Phenotypes and Uses Thereof
  申请人：Melville Mark

  公开号：US20090186358A1

  公开（公告）日：2009-07-23

  The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes.
• [EN] RECOMBINANT HOST CELLS AND PROCESSES FOR PRODUCING 1,3-BUTADIENE THROUGH A 5-HYDROXYPENT-3-ENOATE INTERMEDIATE<br/>[FR] CELLULES HÔTES RECOMBINANTES ET PROCÉDÉS DE FABRICATION DE 1,3-BUTADIÈNE PAR UN INTERMÉDIAIRE 5-HYDROXYPENT-3-ÉNOATE
  申请人：CODEXIS INC

  公开号：WO2013130426A1

  公开（公告）日：2013-09-06

  The present disclosure relates to recombinant host cells comprising one or more recombinant polynucleotides encoding enzymes in select pathways that provide the ability to use the cells to produce 1,3-butadiene. The present disclosure also provides methods of manufacturing the recombinant host cells, and methods for the use of the cells to produce 1,3-butadiene. The methods utilize recombinant host cells that comprise an engineered pathway of enzymes that provides for the conversion of naturally occurring intermediate crotonyl-CoA (or -ACP) to 1,3-butadiene through enzyme catalyzed steps involving the reduction of glutaconyl-CoA (or -ACP) to form the intermediate 5-hydroxypent-3-enoate. The disclosure provides alternative engineered pathway involving either decarboxylation of 5-hydroxypent-3-enoate directly to 1,3-butadiene, or phosphorylation of 5-hydroxypent-3-enoate followed by a phosphate elimination step catalyzed by a decarboxylase to produce 1,3-butadiene.
• [EN] METHOD FOR N-BUTANOL PRODUCTION USING HETEROLOGOUS EXPRESSION OF ANAEROBIC PATHWAYS<br/>[FR] PROCÉDÉ DE PRODUCTION DE N-BUTANOL UTILISANT L'EXPRESSION HÉTÉROLOGUE DE VOIES ANAÉROBIES
  申请人：SILICOLIFE LDA

  公开号：WO2019185843A1

  公开（公告）日：2019-10-03

  The present invention relates to a method for the production of n-butanol using a transgenic cell with heterologous expression of 2-hydroxyglutarate dehydrogenase, glutaconate-CoA transferase, (R)-2-hydroxyglutaryl-CoA dehydrogenase, glutaryl CoA dehydrogenase, trans- 2-enoyl-CoA reductase (NAD+) and bifunctional aldehyde / alcohol dehydrogenase (NAD+).