(2Z)-5-ethoxy-2-[(thiophen-2-ylmethylamino)methylidene]-1-benzothiophen-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2Z)-5-ethoxy-2-[(thiophen-2-ylmethylamino)methylidene]-1-benzothiophen-3-one
• 化学式: C₁₆H₁₅NO₂S₂
• 分子量: 317.4
• InChiKey: DIDSMIHVEJPTCF-GDNBJRDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  91.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• N-ARYLAMINOMETHYLENE BENZOTHIOPHENONES FOR TREATMENT OF CARDIOVASCULAR DISEASE
  申请人：Klussmann Enno

  公开号：US20130289057A1

  公开（公告）日：2013-10-31

  The invention relates to N-arylaminomethylenebenzothiophenones of General Formula (I) for use as a drug for the treatment of cardiovascular diseases: wherein E is S, O, or CH 2 , D is CH or NH, and Ar is a phenyl or naphtyl moiety substituted by an electron-withdrawing group, an unsubstituted heteroaryl residue, or a heteroaryl residue substituted by alkyl or an electron-withdrawing group.
• US9102667B2
  申请人：——

  公开号：US9102667B2

  公开（公告）日：2015-08-11
• [EN] N-ARYLAMINOMETHYLENE BENZOTHIOPHENONES FOR TREATMENT OF CARDIOVASCULAR DISEASE<br/>[FR] N-ARYLAMINOMÉTHYLÈNE-BENZOTHIOPHÉNONES POUR TRAITER LES MALADIES CARDIOVASCULAIRES
  申请人：MAX DELBRUECK CENTRUM

  公开号：WO2012098172A2

  公开（公告）日：2012-07-26

  The invention relates to N-arylaminomethylenebenzothiophenones of General Formula (I) for use as a drug for the treatment of cardiovascular diseases, wherein E is S, O, or CH2, D is CH or NH, and Ar is a phenyl or naphtyl moiety substituted by an electron-withdrawing group, an unsubstituted heteroaryl residue, or a heteroaryl residue substituted by alkyl or an electron-withdrawing group.