1,3-二氯-4,4,5,5-四甲基-2-咪唑烷酮 | 58816-20-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 1,3-二氯-4,4,5,5-四甲基-2-咪唑烷酮
• 英文名称: 1,3-dichloro-4,4,5,5-tetramethyl-2-imidazolidinone
• 英文别名: 1,3-dichloro-4,4,5,5-tetramethylimidazolidin-2-one
• CAS: 58816-20-9
• 化学式: C₇H₁₂Cl₂N₂O
• 分子量: 211.091
• InChiKey: BROYWHABVCPAPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4,4,5,5-tetramethyl-2-imidazolidinone 在 氯 作用下， 以 水 为溶剂， 5.0 ℃ 、137.89 kPa 条件下， 反应 3.0h， 以75%的产率得到1,3-二氯-4,4,5,5-四甲基-2-咪唑烷酮
  参考文献：
  名称：

  新的N-哈拉明化合物的合成及抑菌活性

  摘要：

  描述了在四甲基咪唑啉酮类中的三种新的N，N′-二卤胺化合物的合成。将化合物在水溶液中对金黄色葡萄球菌的稳定性和消毒效果与近年来在这些实验室和其他地方进行了广泛研究的3-氯-4,4-二甲基-2-恶唑烷酮进行了比较。新化合物作为通用消毒剂具有广阔的前景，特别是在需要长期稳定性的应用中。

  DOI：

  10.1002/jps.2600760314

文献信息

• N,N'-Dihalo-2-imidazolidinones
  申请人：PPG INDUSTRIES, INC.

  公开号：EP0239896A1

  公开（公告）日：1987-10-07

  N-chloro and N-bromo derivatives of 2-imidazolidinones having substituents at the 4 and 5 positions of the ring are described. More particularly, there are described dichloro, dibromo-, and chlorobromo- derivatives of 2-imidazolidinones having at least three substituents selected from alkyl, alkoxy, hydroxy and substituted phenyl, e.g., para-substituted phenyl, at the 4 and 5 positions on the ring. These N-halo compounds are biocides, e.g., bactericides, and are useful as disinfectants and sanitizers.

  2-imidazolidinones 的 N-chloro 和 N-bromo 衍生物在环的 4 和 5 位上有取代基。 更具体地说，2-imidazolidinones 的二氯、二溴和氯溴衍生物在环的 4 和 5 位上至少有三个取代基，这些取代基选自烷基、烷氧基、羟基和取代苯基，例如对位取代苯基。 这些 N-halo 化合物是杀生物剂，例如杀菌剂，可用作消毒剂和杀菌剂。
• Biocidal methods for recirculating water systems
  申请人：UNIVERSITY OF HOUSTON

  公开号：EP0403465A1

  公开（公告）日：1990-12-19

  Improved biocidal composition and method for controlling biofouling and microorganism population levels in recirculating water systems such as cooling towers, swimming pools or spas is disclosed and claimed. The composition comprises a hypochlorite donor and a bromide ion donor in proportions selected to maintain a mole ratio of the sum of all bromine containing species to the sum of all hypohalite species in the recirculating water of about 0.2 to about 20. The method comprises introducing into the recirculating water a mixture or combination of a hypochlorite donor and a bromide ion donor in an amount sufficient to maintain a ratio of the sum of all bromine containing species to the sum of all species in the recirculating water in the range of about 0.2 to about 20. In addition, a bromine volatilization suppressant may be introduced into the recirculating water to inhibit loss of bromide ion through volatilization of bromine containing species formed by reaction of the hypochlorite donor and the bromide ion donor. One or more scale inhibitors and compacting aids may also be added.

  本发明公开了用于控制冷却塔、游泳池或水疗池等循环水系统中生物污垢和微生物数量的改进型杀菌组合物和方法。该组合物由次氯酸盐供体和溴离子供体组成，其比例可选，以保持循环水中所有含溴物种之和与所有次氯酸盐物种之和的摩尔比约为 0.2 至约 20。该方法包括向循环水中引入次氯酸盐供体和溴离子供体的混合物或组合，其用量足以维持循环水中所有含溴物种之和与所有物种之和的比率在约 0.2 至约 20 的范围内。此外，还可在循环水中加入溴挥发抑制剂，以抑制次氯酸盐供体和溴离子供体反应形成的含溴物种挥发而造成的溴离子损失。还可添加一种或多种阻垢剂和密实助剂。
• Ophthalmic devices containing heterocyclic compounds and methods for their production
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：EP1327893A1

  公开（公告）日：2003-07-16

  This invention relates to ophthalmic devices and methods for their production where the ophthalmic device contain a polymer and at least one heterocyclic compound comprising at least one N-Cl and/or N-Br bond.

  本发明涉及眼科设备及其生产方法，其中眼科设备包含聚合物和至少一种杂环化合物，杂环化合物包含至少一个 N-Cl 和/或 N-Br 键。
• COMPOSITION FOR THE PREVENTION AND ELIMINATION OF ODORS
  申请人：OxiScience LLC

  公开号：EP3348144A2

  公开（公告）日：2018-07-18

  Articles can be provided with a high level of odor resistance by applying a dispersion of a halogenated heterocyclic N-halamine in an inert liquid carrier to the surface of the article and allowing the inert liquid carrier to penetrate into the article. However, it is important for the inert liquid carried not to react with halogen atoms in the halogenated heterocyclic N-halamine, and for the halogenated heterocyclic N-halamine to become deposited on the surface of the article after the inert liquid carrier penetrates into the article. This method can be used to provide a high level of odor resistance to a wide variety of substrates. It is of particular value for use in manufacturing garbage bags having a high level of odor resistance. It can also be used to deposit other functional particulates onto the surface of substrates that have porosity sufficient to take up the vehicle, including oxidants that may display antimicrobial and enzyme inhibitory efficacy, including, but not limited to N-halamines, and toxin interaction potentials both through oxidative degradation of toxic substances in air and water, and through adsorption interactions, such as fluoride uptake by metal oxide microparticles.

  将卤化杂环 N-卤胺在惰性液体载体中的分散液涂在物品表面，并让惰性液体载体渗入物品内部，可使物品具有较高的防臭性。然而，重要的是惰性液体载体不能与卤化杂环 N-卤胺中的卤素原子发生反应，并且在惰性液体载体渗入物品后，卤化杂环 N-卤胺要沉积在物品表面。这种方法可用于为各种基材提供高水平的抗异味能力。这种方法尤其适用于制造具有高抗臭性的垃圾袋。它还可用于将其他功能性微粒沉积到基材表面，这些基材具有足以吸收载体的孔隙率，其中包括可能具有抗菌和酶抑制功效的氧化剂，包括但不限于 N-卤胺，以及通过氧化降解空气和水中的有毒物质和通过吸附相互作用（如金属氧化物微粒对氟化物的吸收）产生的毒素相互作用潜力。
• Disinfecting and deodorizing compositions and methods with novel polymeric binding system
  申请人：Cao Zhengbing

  公开号：US10028482B2

  公开（公告）日：2018-07-24

  The present invention includes multifunctional compositions, methods and binding systems to provide disinfecting and deodorizing coatings for hard and soft surfaces, inorganic and organic solid surfaces and particulate media and other related substrates, including human and animal skin and skin lesions; to provide neutralizing functions for malodors generated by both human, animal and industrial fluids and solid wastes; and to provide neutralizing and degrading functions for nuisance and noxious chemicals. The present invention provides compositions and methods for producing disinfecting, oxidizing and enzyme-inhibiting fluids enabling preparation of durable, stable biocidal and deodorizing coatings and media which can be widely used for biological agent control, prevention and elimination of odors, and degradation of noxious agents susceptible to chemical oxidation, and which take forms that are inoffensive to users and offer high convenience.

  本发明包括多功能组合物、方法和结合系统，可为软硬表面、无机和有机固体表面和颗粒介质及其他相关基质（包括人类和动物皮肤和皮肤损伤）提供消毒和除臭涂层；为人类、动物和工业液体及固体废物产生的恶臭提供中和功能；以及为有害和有毒化学品提供中和和降解功能。本发明提供了生产消毒液、氧化液和酶抑制液的组合物和方法，从而能够制备持久、稳定的杀菌和除臭涂层和介质，这些涂层和介质可广泛用于生物制剂控制、防止和消除异味以及降解易受化学氧化影响的有害制剂，而且其形式不会引起使用者的反感，并提供了极大的便利。