methyl (3R)-3-(3-hydroxyphenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl (3R)-3-(3-hydroxyphenyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• 化学式: C₁₅H₂₁NO₅
• 分子量: 295.33
• InChiKey: ZMTYKJJOKXHQAL-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOUNDS FOR BINDING TO THE PLATELET SPECIFIC GLYCOPROTEIN IIB/IIIA AND THEIR USE FOR IMAGING OF THROMBI
  申请人：Berger Markus

  公开号：US20140314669A1

  公开（公告）日：2014-10-23

  The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein 11b/IIIa antagonists for imaging of thrombi.

  本发明涉及新型含氟化合物、其制备方法、合成中间体、其作为诊断剂的用途，特别是用于血栓成像。本发明涉及正电子发射断层扫描(PET)试剂和相关的前体试剂，以及用于在哺乳动物体内成像血栓的放射性标记试剂的制备方法。更具体地说，本发明涉及用于血栓成像的小分子非肽、高亲和力、特异性结合的糖蛋白11b/IIIa拮抗剂。