(R)-3,4-Dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-3,4-Dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid
• 英文别名: (3R)-3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid
• 化学式: C₆H₇NO₄S
• 分子量: 189.19
• InChiKey: PKFNRZOFABOFSP-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSITIONS UTILES EN THÉRAPIE DE PATHOLOGIES LIÉES À L'AUTOPHAGIE, ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：UNIV TOLEDO

  公开号：WO2017147440A1

  公开（公告）日：2017-08-31

  Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).

  兰硫氨酸酮亚胺衍生物的制备方法和用途被描述。包括兰硫氨酸酮亚胺磷酸酯（LK-P）、兰硫氨酸酮亚胺酯磷酸酯（LKE-P）衍生物，以及在2位点具有叔-烯酰胺基团的兰硫氨酸酮亚胺衍生物（NVP-LKE）。
• Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same
  申请人：The University of Toledo

  公开号：US10882831B2

  公开（公告）日：2021-01-05

  Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, and methods of making and using the same, are described.

  描述了膦酸镧酮亚胺（LK-P）、膦酸镧酮亚胺酯（LKE-P）、其他膦酸镧酮亚胺、膦酸镧酮亚胺和膦酸镧酮亚胺酯衍生物，以及制造和使用它们的方法。
• COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME
  申请人：The University of Toledo

  公开号：US20190040091A1

  公开（公告）日：2019-02-07

  Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).
• COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME
  申请人：The University of Toledo

  公开号：US20210171553A1

  公开（公告）日：2021-06-10

  Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, methods of making and using the same, and methods of treatments are described.