1,3-双(2-羟基乙氧基)丙烷-2-醇 | 62702-36-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: 1,3-双(2-羟基乙氧基)丙烷-2-醇
• 英文名称: 1,3-bis-(2-hydroxy-ethoxy)-propan-2-ol
• 英文别名: O¹,O³-Bis-(2-hydroxy-aethyl)-glycerin；1,3-Bis-(2-hydroxy-aethoxy)-propan-2-ol；Glycerin-1.3-bis-(2-hydroxy-aethylaether)；1,3-Bis(2-hydroxyethoxy)propan-2-ol
• CAS: 62702-36-7
• 化学式: C₇H₁₆O₅
• 分子量: 180.201
• InChiKey: ODMOFUHYUDOOFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3-双(2-羟基乙氧基)丙烷-2-醇 生成 2-(4-nitro-benzoyloxy)-1,3-bis-[2-(4-nitro-benzoyloxy)-ethoxy]-propane
  参考文献：
  名称：

  Petrow; Stephenson, Journal of Pharmacy and Pharmacology, 1955, vol. 7, p. 198,203

  摘要：

  DOI：
• 作为产物：
  描述：

  环氧氯丙烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙二醇 作用下， 生成 1,3-双(2-羟基乙氧基)丙烷-2-醇
  参考文献：
  名称：

  CONDENSATION OF EPICHLOROHYDRIN WITH ETHYLENE GLYCOL: SOME NEW POLYFUNCTIONAL DERIVATIVES

  摘要：

  DOI：

  10.1021/jo01190a011

文献信息

• THERMOPLASTIC RESIN FILM WITH SATISFACTORY PRINTABILITY
  申请人：Yupo Corporation

  公开号：EP1172400A1

  公开（公告）日：2002-01-16

  Described is a thermoplastic resin film having on a surface thereof a hydroxy-modified imine polymer containing repeating units represented by the following general formula (I) in an amount of 5 mol% or more based on the total of repeating units. This thermoplastic resin film has ink transfer, adhesion and aging stability, and excellent printability of generating no back ghost when offset printing using oxidation polymerization type ink is performed on both faces.

  所述的是一种热塑性树脂薄膜，其表面含有羟基改性亚胺聚合物，该聚合物含有以下通式 (I) 所代表的重复单元，其含量为重复单元总量的 5 mol% 或以上。这种热塑性树脂薄膜具有油墨转移性、附着性和老化稳定性，而且在使用氧化聚合型油墨进行胶版印刷时，两面都不会产生重影，具有极佳的印刷适性。
• Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
  申请人：Idera Pharmaceuticals, Inc.

  公开号：EP2341059A1

  公开（公告）日：2011-07-06

  The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

  本发明提供了作为 TLRs 拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。这些IRO具有独特的序列，可抑制或抑制TLR介导的对TLR配体或TLR激动剂的信号传导。这些方法可用于预防和治疗癌症、自身免疫性疾病、气道炎症、炎症性疾病、传染性疾病、皮肤病、过敏、哮喘或由病原体引起的疾病。
• Stabilized immune modulatory RNA (SIMRA) compounds
  申请人：Idera Pharmaceuticals, Inc.

  公开号：EP2348112A2

  公开（公告）日：2011-07-27

  The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLRB.

  本发明涉及新型稳定化寡核苷酸作为免疫调节剂在免疫治疗中的应用。具体而言，本发明提供了新型 RNA 基寡核苷酸，其核酸酶和 RNase 稳定性得到改善，并通过 TLR7 和/或 TLRB 具有免疫调节活性。
• COMPOSITION FOR INHIBITING GENE EXPRESSION AND USES THEREOF
  申请人：Idera Pharmaceuticals, Inc.

  公开号：EP2960333A1

  公开（公告）日：2015-12-30

  The inventors have examined the means for providing more efficacious gene expression blocking compounds. The inventors have discovered new structural features that surprisingly improve the efficacy of gene expression blocking molecules. These features include the presence of multiple 3' ends and a linker at the 5' ends. Surprisingly, these features improve the efficacy of the gene expression blocking compounds in a manner that decreases the compound's biologic instability. Even more surprisingly, this effect has been found to be applicable to both DNA and RNA oligonucleotide-based compounds and to have application in traditional antisense and RNAi technologies.

  本发明者研究了提供更有效基因表达阻断化合物的方法。本发明者发现了新的结构特征，这些特征令人惊讶地提高了基因表达阻断分子的功效。这些特征包括多个 3'末端和 5'末端的连接体。令人惊讶的是，这些特征以降低化合物生物不稳定性的方式提高了基因表达阻断化合物的功效。更令人惊讶的是，这种效果已被发现适用于 DNA 和 RNA 寡核苷酸化合物，并可应用于传统的反义和 RNAi 技术。
• COMPOSITIONS FOR INHIBITING GENE EXPRESSION AND USES THEREOF
  申请人：Idera Pharmaceuticals, Inc.

  公开号：EP3272870A1

  公开（公告）日：2018-01-24

  The inventors have examined the means for providing more efficacious gene expression blocking compounds. The inventors have discovered new structural features that surprisingly improve the efficacy of gene expression blocking molecules. These features include the presence of multiple 3' ends and a linker at the 5' ends. Surprisingly, these features improve the efficacy of the gene expression blocking compounds in a manner that decreases the compound's biologic instability. Even more surprisingly, this effect has been found to be applicable to both DNA and RNA oligonucleotide-based compounds and to have application in traditional antisense and RNAi technologies.

  本发明者研究了提供更有效基因表达阻断化合物的方法。本发明者发现了新的结构特征，这些特征令人惊讶地提高了基因表达阻断分子的功效。这些特征包括多个 3'末端和 5'末端的连接体。令人惊讶的是，这些特征以降低化合物生物不稳定性的方式提高了基因表达阻断化合物的功效。更令人惊讶的是，这种效果已被发现适用于 DNA 和 RNA 寡核苷酸化合物，并可应用于传统的反义和 RNAi 技术。