1,3-双(2-羟基苯基)金刚烷 | 123822-60-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 中文名称: 1,3-双(2-羟基苯基)金刚烷
• 英文名称: 1,3-bis(2-hydroxyphenyl)adamantane
• 英文别名: 2-[3-(2-hydroxyphenyl)-1-adamantyl]phenol
• CAS: 123822-60-6
• 化学式: C₂₂H₂₄O₂
• 分子量: 320.431
• InChiKey: QKQVDDBQKGAIAL-UHFFFAOYSA-N

物化性质

• 熔点：
  198-199 °C
• 沸点：
  477.8±45.0 °C(Predicted)
• 密度：
  1.260±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  7-亚甲基双环[3.3.1]壬-3-酮 、 苯酚 生成 1,3-双(2-羟基苯基)金刚烷
  参考文献：
  名称：

  KOZLIKOVSKIJ, YA. B.;KOSHCHIJ, V. A.;RODIONOV, V. N.;YURCHENKO, A. G.;OLI+, ZH. ORGAN. XIMII, 25,(1989) N, S. 1222-1226

  摘要：

  DOI：

文献信息

• Hydroxyphenyl adamantanes and process for the production of the same
  申请人：——

  公开号：US20030187307A1

  公开（公告）日：2003-10-02

  Hydroxyphenyl adamantanes are represented by the general formula (1): 1 wherein R is an alkyl group, cycloalkyl group or phenyl group; m is 0 or an integer 1 or 2; l is 0 or 1; when l is 1, hydroxy groups of substituted hydroxyphenyl groups at positions 1 and 3 are together in para-position; n is 0 or an integer 1, 2 or 3; and when l is 0, n is an integer 1, 2 or 3.

  羟基苯基重氮烷类化合物由通式（1）表示： 1 其中R为烷基、环烷基或苯基；m为0或整数1或2；l为0或1；当l为1时，取代羟基苯基的1和3位的羟基在对位上共同存在；n为0或整数1、2或3；当l为0时，n为整数1、2或3。
• Multi-arm polymer prodrugs
  申请人：Zhao Xuan

  公开号：US20050112088A1

  公开（公告）日：2005-05-26

  Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.

  本文提供了水溶性前药。该发明的前药包括具有三个或更多臂的水溶性聚合物，其中至少三个臂与活性剂，例如小分子，共价连接。本发明的共轭物提供了一种优化的聚合物大小和结构的平衡，以实现改善的药物装载，因为本发明的共轭物具有三个或更多的活性剂可释放地连接到多臂水溶性聚合物上。本发明的前药具有治疗效果，并在体内表现出比未经修改的母药更好的性质。
• Intermediates Useful in the Preparation of Maleimide Functionalized Polymers
  申请人：McManus Samuel P.

  公开号：US20120004422A1

  公开（公告）日：2012-01-05

  Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.

  提供了制备马来酰亚胺官能化聚合物的方法。在其中一种实施例中，通过进行反Diels-Alder反应的步骤来准备马来酰亚胺官能化聚合物。还提供了在该方法中有用的中间体，以及制备中间体的方法。还提供了聚合物试剂、使用聚合物试剂的方法、化合物和共轭物。
• 1,3-BIS(HYDROXYPHENYL)-5-ETHYLADAMANTANE COMPOUND AND METHOD FOR PRODUCTION THEREOF, AND AROMATIC POLYCARBONATE RESIN AND METHOD FOR PRODUCTION THEREOF
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20160244389A1

  公开（公告）日：2016-08-25

  The present invention can provide a 1,3-bis(hydroxyphenyl)-5-ethyladamantane compound represented by Formula (1) below and a method for producing the same, as well as an aromatic polycarbonate resin comprising said compound and a method for producing the same. (wherein, R represents an alkyl group with a carbon number of 1-6, a cycloalkyl group with a carbon number of 3-6, or a phenyl group, and n represents an integer of 0-2).

  本发明提供了一种由下式（1）表示的1,3-双（羟基苯基）-5-乙基金刚烷化合物及其制备方法，以及包含所述化合物的芳香族聚碳酸酯树脂及其制备方法。（其中，R代表碳数为1-6的烷基，碳数为3-6的环烷基或苯基，n代表0-2的整数）。
• Methods of preparing maleimide functionalized polymers
  申请人：McManus P. Samuel

  公开号：US20050176922A1

  公开（公告）日：2005-08-11

  Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.

  提供了制备马来酰亚胺官能化聚合物的方法。在其中一种实施例中，通过进行反向Diels-Alder反应的步骤来制备马来酰亚胺官能化聚合物。还提供了在该方法中有用的中间体，以及制备中间体的方法。还提供了聚合物试剂、使用聚合物试剂的方法、化合物和共轭物。