1,3-环戊二烯-1,3-二甲酸 | 130708-70-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,3-环戊二烯-1,3-二甲酸
• 英文名称: Cyclopenta-1,3-diene-1,3-dicarboxylic acid
• CAS: 130708-70-2
• 化学式: C₇H₆O₄
• mdl: MFCD18805584
• 分子量: 154.12
• InChiKey: SBNWOLOYXPPBMG-UHFFFAOYSA-N

物化性质

• 熔点：
  203-205 °C
• 沸点：
  362.7±42.0 °C(Predicted)
• 密度：
  1.608±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  环戊二烯 、 1,3-环戊二烯-1,3-二甲酸 生成 tricyclo[5.2.1.02,6]deca-3,8-diene-1,8-dicarboxylic acid
  参考文献：
  名称：

  HARUKI, EIICHI;HARA, TADASHI;INOUE, HIROO, CHEM. EXPRESS., 5,(1990) N, C. 493-496

  摘要：

  DOI：
• 作为产物：
  描述：

  Cyclopenta-1,3-diene-1,2,3-tricarboxylic acid 、 水 生成 1,3-环戊二烯-1,3-二甲酸
  参考文献：
  名称：

  HARUKI, EIICHI;HARA, TADASHI;INOUE, HIROO, CHEM. EXPRESS., 5,(1990) N, C. 493-496

  摘要：

  DOI：

文献信息

• HARUKI, EIICHI;HARA, TADASHI;INOUE, HIROO, CHEM. EXPRESS., 5,(1990) N, C. 493-496
  作者：HARUKI, EIICHI、HARA, TADASHI、INOUE, HIROO

  DOI：——

  日期：——
• PRODRUGS UTILIZING A TRANSPORTER DIRECTED UPTAKE MECHANISM
  申请人：Virginia Commonwealth University

  公开号：EP2624869A2

  公开（公告）日：2013-08-14
• PRODRUGS UTILIZING A TRANSPORTER-DIRECTED UPTAKE MECHANISM
  申请人：VIRGINIA COMMONWEALTH UNIVERSITY

  公开号：US20130267547A1

  公开（公告）日：2013-10-10

  Prodrugs comprising a lipophilic drug linked to a transport moiety that can be taken up by a fatty acid transporter are provided. The transport moiety comprises a lipid chain connected to a hydrophilic group (e.g. a carboxylic acid, a phosphate, or a sphingosine-like moiety). Due to the presence of the transport moiety, the prodrugs are substrates for endogenous fatty acid transporter systems. The transport moiety thus serves as a carrier or targeting moiety to facilitate uptake of the entire prodrug complex by endogenous fatty acid transporter systems, thereby moving the prodrug into cells and tissues where drug distribution and effects are desired. Hydrolysis of the chemical linkage between the lipid-like moiety and the lipophilic drug releases the drug in an active form within the cells or tissues.
• [EN] PRODRUGS UTILIZING A TRANSPORTER DIRECTED UPTAKE MECHANISM<br/>[FR] PROMÉDICAMENTS UTILISANT UN MÉCANISME D'ABSORPTION CONTRÔLÉ PAR TRANSPORTEUR
  申请人：UNIV VIRGINIA COMMONWEALTH

  公开号：WO2012048204A2

  公开（公告）日：2012-04-12

  Prodrugs comprising a lipophilic drug linked to a transport moiety that can be taken up by a fatty acid transporter are provided. The transport moiety comprises a lipid chain connected to a hydrophilic group (e.g. a carboxylic acid, a phosphate, or a sphingosine-like moiety). Due to the presence of the transport moiety, the prodrugs are substrates for endogenous fatty acid transporter systems. The transport moiety thus serves as a carrier or targeting moiety to facilitate uptake of the entire prodrug complex by endogenous fatty acid transporter systems, thereby moving the prodrug into cells and tissues where drug distribution and effects are desired. Hydrolysis of the chemical linkage between the lipid-like moiety and the lipophilic drug releases the drug in an active form within the cells or tissues.