MOUSE PLASMA AND MOUSE LIVER HOMOGENATE CATALYZED CLEAVAGE OF FENAZAFLOR TO 5,6-DICHLORO-2-TRIFLUOROMETHYLBENZIMIDAZOLE (5,6-CL2-TFB). IN PRESENCE OF NADPH, LIVER MICROSOME SYSTEM CONVERTED 5,6-CL2-TFB TO CMPD SUGGESTIVE OF CL-OH-TFB. METHYLATION YIELDED 2 /UNIDENTIFIED/ PRODUCTS... LABELED FENAZAFLOR...WAS ADMIN ORALLY TO RATS & MICE. ... THOSE MATERIALS...FOUND IN BOTH RAT & MOUSE URINE: N-GLUCURONIDE OF 5,6-CL2-TFB; CONJUGATES OF 5-CL-6-OH-TFB /5-CHLORO-6-HYDROXY-2-TRIFLUOROMETHYLBENZIMIDAZOLE/; 4-OH-5,6-CL2-TFB /4-HYDROXY-5,6-DICHLORO-2-TRIFLUOROMETHYLBENZIMIDAZOLE/; 4,7-(OH)2-5,6-CL2-TFB /4,7-DIHYDROXY-5,6-DICHLORO-2-TRIFLUOROMETHYLBENZIMIDAZOLE/; CONJUGATES OF HYDROXY DERIVATIVE(S) OF 5,6-CL2-TFB.
In warm-blooded animals ... /metabolized/ by hydrolytic splitting-off of benzoyl moiety, hydroxylation of benzene nucleus, and elimination in the urine as the glucoside.
1. WASH CONTAMINATED SKIN WITH SOAP & WATER. 2. FLUSH CONTAMINATED EYES WITH COPIOUS AMOUNTS OF FRESH WATER FOR 15 MINUTES. 3. INGESTIONS OF SMALL AMOUNTS (LESS THAN 10 MG/KG BODY WEIGHT) OCCURRING LESS THAN AN HOUR BEFORE TREATMENT, ARE PROBABLY BEST TREATED BY: A. SYRUP OF IPECAC, FOLLOWED BY 1-2 GLASSES OF WATER. DOSE FOR ADULTS & CHILDREN OVER 12 YEARS: 30 ML. DOSE FOR CHILDREN UNDER 12 YEARS: 15 ML. B. ACTIVATED CHARCOAL: /PRC: 30 G ACTIVATED CHARCOAL IN 3-4 OZ WATER (CHILDREN), 100 G IN 8-10 OZ WATER (ADULT)/...AFTER VOMITING STOPS. C. SODIUM OR MAGNESIUM SULFATE, 0.25 G/KG IN TAP WATER, AS A CATHARTIC. /PESTICIDES OF LOW OR MODERATE TOXICITY/
4. INGESTIONS OF LARGE AMOUNTS (MORE THAN 10 MG/KG) OCCURRING LESS THAN AN HR BEFORE TREATMENT, SHOULD PROBABLY BE TREATED BY GASTRIC LAVAGE: A. INTUBATE STOMACH & ASPIRATE CONTENTS. B. LAVAGE STOMACH WITH SLURRY OF ACTIVATED CHARCOAL.../&/ LEAVE 30-50 G ACTIVATED CHARCOAL IN THE STOMACH BEFORE WITHDRAWING TUBE. C. SODIUM SULFATE, 0.25 G/KG IN TAP WATER, AS A CATHARTIC. CAUTION: HYDROCARBONS (KEROSENE, PETROLEUM DISTILLATES) ARE INCLUDED IN SOME FORMULATIONS OF THESE CHEMICALS. INGESTION OF VERY LARGE AMOUNTS MAY CAUSE CNS DEPRESSION. IN THIS CASE, IPECAC IS CONTRAINDICATED. ALSO, GASTRIC INTUBATION INCURS A RISK OF HYDROCARBON PNEUMONITIS. FOR THIS REASON OBSERVE THE FOLLOWING PRECAUTIONS: (1) IF THE VICTIM IF UNCONSCIOUS OR OBTUNDED & FACILITIES ARE AT HAND, INSERT AN ENDOTRACHEAL TUBE (CUFFED, IF AVAILABLE) PRIOR TO GASTRIC INTUBATION. (2) KEEP VICTIM'S HEAD BELOW LEVEL OF STOMACH DURING INTUBATION & LAVAGE /PRC: TAP WATER IN CHILDREN, ISOTONIC SALINE IN ADULTS/ (TRENDELENBURG, OR LEFT LATERAL DECUBITUS, WITH HEAD OF TABLE TIPPED DOWNWARD). KEEP VICTIM'S HEAD TURNED TO THE LEFT. (3) ASPIRATE PHARYNX AS REGULARLY AS POSSIBLE TO REMOVE GAGGED OR VOMITED STOMACH CONTENTS. /PESTICIDES OF LOW OR MODERATE TOXICITY/
5. INGESTIONS OCCURRING MORE THAN AN HR BEFORE TREATMENT ARE PROBABLY BEST TREATED ONLY BY ACTIVATED CHARCOAL /PRC: 30 G ACTIVATED CHARCOAL IN 3-4 OZ WATER (CHILDREN), 100 G IN 8-10 OZ WATER (ADULT)/...& SODIUM OR MAGNESIUM SULFATE, 0.25 G/KG... 6. THERE ARE NO SPECIFIC ANTIDOTES FOR THESE CHEMICALS. BECAUSE MANIFESTATIONS OF TOXICITY DO OCCASIONALLY OCCUR IN PECULIARLY PREDISPOSED INDIVIDUALS, MAINTAIN CONTACT WITH VICTIM FOR AT LEAST 72 HR SO THAT UNEXPECTED ADVERSE EFFECTS CAN BE TREATED PROMPTLY. /PESTICIDES OF LOW OR MODERATE TOXICITY/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
非人类毒性摘录
喂食了两年含有250 ppm的饲料的老鼠没有出现可检测到的临床症状。
RATS FED FOR 2 YEARS ON DIET CONTAINING 250 PPM SUFFERED NO DETECTABLE CLINICAL SYMPTOMS.
CUMULATIVE TOXICITY IN RAT, BY ORAL DOSAGE DAILY, IS ONLY MODERATE. CUMULATIVE LD50 PROVES TO BE 780 MG/KG/DAY. THE LC50 (24 HR EXPOSURE) FOR GUPPIES IS 0.2 PPM.
Compounds of formula I
wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.
Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
申请人：Dow AgroSciences LLC
公开号：US20180279612A1
公开（公告）日：2018-10-04
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
