1,4-二硫螺[4.5]-8-癸醇 | 22428-86-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 中文名称: 1,4-二硫螺[4.5]-8-癸醇
• 中文别名: 1,4-二硫杂螺[4.5]癸烷-8-醇
• 英文名称: 4,4-<1,2-ethanediylbis(thio)>cyclohexanol
• 英文别名: 4-hydroxycyclohexanone ethylene thioacetal；1,4-dithiaspiro<4.5>decan-8-ol；4-Hydroxycyclohexanonethylenthioacetal；1,4-dithia-spiro[4.5]decan-8-ol；1,4-Dithiaspiro[4.5]decan-8-ol
• CAS: 22428-86-0
• 化学式: C₈H₁₄OS₂
• mdl: MFCD00013350
• 分子量: 190.331
• InChiKey: LAURNNUYMVKSSO-UHFFFAOYSA-N

物化性质

• 熔点：
  83-85℃
• 沸点：
  98 °C(Press: 0.75 Torr)
• 密度：
  1.26

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  1,4-二硫螺[4.5]-8-癸醇 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.58h， 以99%的产率得到1,4-二硫杂螺[4.5]癸烷-8-酮
  参考文献：
  名称：

  通过 Prins-Pinacol 反应构建 12-氧杂三环 [6.3.1.02,7] 十二烷环系统中立体控制的起源

  摘要：

  含有 12-氧杂三环 [6.3.1.0 2,7 ] 十二烷部分的多环产物具有氧杂环桥的反式 ( 8a - e ) 或顺式 ( 9a - e ) 相对构型和顺式有角取代基由 Prins- 立体特异性地形成不饱和 α-二噻吩缩醛14a - e或15a - e 的频哪醇环化。这些结果表明，从缩醛14a - e或15a - e生成的硫稳定氧碳鎓离子的 Prins 环化的形貌（船或椅子）受烯丙基取代基的立体电子影响控制，空间效应起次要作用。还鉴定了由硫代-Prins-频哪醇反应终止的复杂分子重排。

  DOI：

  10.1021/jo9024144
• 作为产物：
  描述：

  1,4-环己二酮 在 lithium aluminium tetrahydride 、 对甲苯磺酸 作用下， 以 乙醚 、 苯 为溶剂， 反应 1.0h， 生成 1,4-二硫螺[4.5]-8-癸醇
  参考文献：
  名称：

  Takemura, Tetsuo; Hosoya, Yoshiko; Mori, Nobuo, Canadian Journal of Chemistry, 1990, vol. 68, # 4, p. 523 - 529

  摘要：

  DOI：

文献信息

• Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor
  申请人：——

  公开号：US20030229119A1

  公开（公告）日：2003-12-11

  The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

  本发明涉及通过黑素浓缩激素受体对黑素浓缩激素（MCH）效果的拮抗，对于预防或治疗进食障碍、体重增加、肥胖、生殖和性行为异常、甲状腺激素分泌、利尿和水/电解质平衡、感觉处理、记忆、睡眠、觉醒、焦虑、抑郁、癫痫发作、神经退行性疾病和精神疾病是有用的。
• Oxidation of Alcohols with o-Iodoxybenzoic Acid in DMSO: A New Insight into an Old Hypervalent Iodine Reagent
  作者：Marco Frigerio、Marco Santagostino、Simona Sputore、Giovanni Palmisano

  DOI：10.1021/jo00127a036

  日期：1995.11

  The ultracentennial 10-I-4 iodinane oxide IBX (3; o-iodoxybenzoic acid; 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide) represents a new oxidizing-reagent that successfully joins to the large family of known oxidants. IBX, in contrast to other valuable oxidants, is inexpensive to prepare and easy to handle, can tolerate moisture and water, and generally gives very good yields. Furthermore, IBX is mild and chemoselective (primary alcohols are converted into aldehydes with no overoxidation to acids; 1,2-diols are converted to alpha-ketols or alpha-diketones without oxidative cleavage; amino alcohols are oxidized to amino carbonyls, without protection of the amino group; sensitive heterocycles are not affected; various other functional groups are compatible with IBX oxidation). IBX is versatile (it works in various solvents and it is highly sensitive to temperature variations), and its solutions in DMSO are stable enough to carry out the oxidation reaction easily.
• Carbamates from alcohol diversity: a simple solution phase library method
  作者：Gregory L. Hamilton、Bradley J. Backes

  DOI：10.1016/j.tetlet.2005.11.139

  日期：2006.2

  A simple one-pot, solution phase method for the parallel synthesis of carbamates from amines and alcohols is described. The high-yielding method does not require support-bound reagents, extractions or resin washing steps and should be broadly applicable to the manual or automated generation of carbamate libraries. (c) 2005 Elsevier Ltd. All rights reserved.
• Crombie, Leslie; Crombie, W. Mary L.; Jamieson, Sally V., Journal of the Chemical Society. Perkin transactions I, 1982, p. 1485 - 1492
  作者：Crombie, Leslie、Crombie, W. Mary L.、Jamieson, Sally V.、Tuchinda Patoomratana、Whitaker, Alison J.

  DOI：——

  日期：——
• Annulation of .alpha.-formyl .alpha.,.beta.-unsaturated ketones by a Michael addition-cyclization sequence. A versatile synthesis of alicyclic six-membered rings
  作者：Walter L. Meyer、Michael J. Brannon、Celmira da G. Burgos、Thomas E. Goodwin、Ralph W. Howard

  DOI：10.1021/jo00204a003

  日期：1985.2