1,4-双(溴甲基)蒽 | 58791-48-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 1,4-双(溴甲基)蒽
• 英文名称: 1,4-Bis-(brommethyl)-anthracen
• 英文别名: Anthracene, 1,4-bis(bromomethyl)-；1,4-bis(bromomethyl)anthracene
• CAS: 58791-48-3
• 化学式: C₁₆H₁₂Br₂
• 分子量: 364.079
• InChiKey: GYPMSGOWCNDLNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,4-双(溴甲基)蒽 在 sodium hydroxide 作用下， 生成 1,4-Bis-methylsulfanylmethyl-anthracene
  参考文献：
  名称：

  Gundermann,K.-D.; Roeker,K.-D., Justus Liebigs Annalen der Chemie, 1976, p. 140 - 152

  摘要：

  DOI：
• 作为产物：
  描述：

  9,10-dioxo-9,10-dihydro-1,4-anthracene dicarboxylic acid 在 盐酸 、 ammonium hydroxide 、 红铝 、 锌 、 二溴三苯基膦 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 1.0h， 生成 1,4-双(溴甲基)蒽
  参考文献：
  名称：

  1,4-Disubstituted Anthracene Antitumor Agents

  摘要：

  Three different types of 1,4-disubstituted anthracenes were synthesized, and their cytotoxicity in a panel of tumor cells was compared with that of the corresponding 9,10-disubstituted anthracenes. The panel contained human myeloma, melanoma, colon, and lung cancer cells and sensitive and multidrug-resistant murine L1210 leukemia cells. These compounds had [[(dimethylamino>ethyl]amino]methyl, N-[(dimethylamino)ethyl]carbamoyl, and carboxaldehyde (4,5-dihydro-1H-imidazol-2-yl)hydrazone side chains. The 1,4-diamide was more potent across the tumor panel than the corresponding 9,10-isomer, but the 1,4-diamine and the 1,4-hydrazone were less potent than their 9,10-isomers. Although the 1,Li-hydrazone was active against P388 leukemia in mice, it was inactive against L1210 leukemia. Within each pair of compounds, the one with greater average potency against tumor cells gave a greater increase in the transition melt temperature of DNA.

  DOI：

  10.1021/jm970308+

文献信息

• SYNTHESIS OF TWO ISOMERIC TETRACYANOANTHRAQUINODIMETHANES
  作者：Shunro Yamaguchi、Hitoshi Tatemitsu、Yoshiteru Sakata、Soichi Misumi

  DOI：10.1246/cl.1983.1229

  日期：1983.8.5

  Synthesis of two new acceptors, i.e., dibenzo- and naphtho-TCNQ, is described. Their redox potentials suggest that benzo and naphtho annelations to TCNQ lower the acceptor strength. Both compounds gave no CT complex with TTT, TTF, etc.

  描述了两种新受体的合成，即二苯并萘基-TCNQ。它们的氧化还原电位表明苯并和萘酚与 TCNQ 的退火降低了受体强度。两种化合物均不产生与 TTT、TTF 等的 CT 复合物。
• Haenel, Matthias W.; Lintner, Birgit; Schweitzer, Dieter, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1986, vol. 41, # 2, p. 223 - 230
  作者：Haenel, Matthias W.、Lintner, Birgit、Schweitzer, Dieter

  DOI：——

  日期：——
• YAMAGUCHI, SHUNRO;TATEMITSU, HITOSHI;SAKATA, YOSHITERU;MISUMI, SOICHI, CHEM. LETT., 1983, N 8, 1229-1230
  作者：YAMAGUCHI, SHUNRO、TATEMITSU, HITOSHI、SAKATA, YOSHITERU、MISUMI, SOICHI

  DOI：——

  日期：——
• HAENEL, M. W.;LINTNER, B.;SCHWEITZER, D., Z. NATURFORSCH., 1986, 41, N 2, 223-230
  作者：HAENEL, M. W.、LINTNER, B.、SCHWEITZER, D.

  DOI：——

  日期：——
• GUNDERMANN K.-D.; ROECKER K.-D., J. LIEBIGS ANN. CHEM. <JLAC-BF>, 1976, NO 1, 140-152
  作者：GUNDERMANN K.-D.、 ROECKER K.-D.

  DOI：——

  日期：——