新亚铜灵盐酸 | 41066-08-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 中文名称: 新亚铜灵盐酸
• 中文别名: 2,9-二甲基-1,10-菲咯啉盐酸盐
• 英文名称: 2,9-dimethyl-1,10-phenanthroline hydrochloride
• 英文别名: 2,9-Dimethyl-1,10-phenanthrolin-10-ium;chloride；2,9-dimethyl-1,10-phenanthrolin-10-ium;chloride
• CAS: 41066-08-4
• 化学式: C₁₄H₁₂N₂*ClH
• mdl: MFCD00012645
• 分子量: 244.724
• InChiKey: QUGBNSJLQDNNPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.55
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  25.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] MACROCYCLIZATION REACTIONS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B<br/>[FR] RÉACTIONS DE MACROCYCLISATION ET INTERMÉDIAIRES UTILES DANS LA SYNTHÈSE D'ANALOGUES DE L'HALICHONDRINE B
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2015066729A1

  公开（公告）日：2015-05-07

  The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

  该发明提供了一种通过大环化策略合成厄立宾或其药用可接受盐（例如，厄立宾甲磺酸盐）的方法。本发明的大环化策略涉及将非大环中间体经过碳-碳键形成反应（例如，烯化反应（例如，Horner-Wadsworth-Emmons烯化反应）、迪克曼反应、催化环闭合烯烃交换反应，或Nozaki-Hiyama-Kishi反应）以获得大环中间体。该发明还提供了在合成厄立宾或其药用可接受盐时作为中间体有用的化合物以及制备这些化合物的方法。
• [EN] PRINS REACTION AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES AND ANALOGS THEREOF<br/>[FR] RÉACTION DE PRINS ET D'INTERMÉDIAIRES UTILES DANS LA SYNTHÈSE DE MACROLIDES D'HALICHONDRINE ET DE SES ANALOGUES
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2018006031A1

  公开（公告）日：2018-01-04

  The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

  本发明提供了一种通过环化反应策略合成半萜类大环内酯或其类似物的方法。本发明的策略包括将中间体置于普林斯反应条件下以得到大环内酯。本发明还提供了在合成半萜类大环内酯或其类似物的过程中有用的中间体化合物以及制备它们的方法。
• Method of and reagent for the prevention of turbidity
  申请人：TECHNICON GMBH

  公开号：EP0404590A2

  公开（公告）日：1990-12-27

  Turbidity caused by protein precipitation in biological fluids such as serum, plasma or other fluids containing proteins in solution, which fluids are to be subjected for example to colorimetric or other analysis, can be prevented or reduced by adding to the sample urea or a urea derivative in addition to a surface-active agent.

  在生物液体（如血清、血浆或其他含有溶液中蛋白质的液体）中进行比色分析或其他分析时，可通过在样品中添加尿素或尿素衍生物以及表面活性剂来防止或减少因蛋白质沉淀而造成的浑浊。
• Macrocyclization reactions and intermediates and other fragments useful in the synthesis of analogs of halichondrin B
  申请人：EISAI R&D MANAGEMENT CO., LTD.

  公开号：US10934307B2

  公开（公告）日：2021-03-02

  The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

  本发明提供了通过大环化策略合成埃里布林或其药学上可接受的盐（如甲磺酸埃里布林）的方法。本发明的大环化策略包括将非大环中间体进行碳-碳键形成反应（例如，烯化反应（例如，Horner-Wadsworth-Emmons 烯化反应）、Dieckmann 反应、催化闭环烯烃 Metathesis 或 Nozaki-Hiyama-Kishi 反应）以得到大环中间体。本发明还提供了可用作合成麦角林或其药学上可接受的盐的中间体的化合物，以及制备这些化合物的方法。
• Method for quantitatively determining a reducing substance and a reagent for quantitative determination
  申请人：Sekiguchi Masahiro

  公开号：US20050148089A1

  公开（公告）日：2005-07-07

  The present invention provides a method for quantitatively determining a reducing substance, which comprises reacting a reducing substance in a test specimen with iron (III) ions, reacting iron (II) ions formed by reduction of the iron (III) ions or residual iron (III) ions with a metal indicator which is capable of reacting specifically with the iron (II) ions or the residual iron (III) ions to undergo color development, and carrying out quantitative determination by measuring the degree of color development, wherein a chelating agent which is specific to copper ions is added to the test specimen before the reaction of the reducing substance with the iron (III) ions; and a reagent used for it.

  本发明提供了一种定量测定还原性物质的方法，该方法包括使试样中的还原性物质与铁（III）离子反应，将铁（III）离子还原形成的铁（II）离子或残余的铁（III）离子与金属指示剂反应，金属指示剂能够与铁（II）离子或残余的铁（III）离子发生特异性反应而显色、通过测量显色程度进行定量测定，其中在还原物质与铁（III）离子反应之前，在试样中加入对铜离子具有特异性的螯合剂；以及一种用于此目的的试剂。

表征谱图