1,6-二氮杂螺[3.3]庚烷-6-甲酸叔丁酯 | 1272412-72-2

• 物质功能分类: 医药中间体 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 中文名称: 1,6-二氮杂螺[3.3]庚烷-6-甲酸叔丁酯
• 中文别名: 6-Boc-1,6-二氮杂螺[3.3]庚烷草酸盐
• 英文名称: Tert-butyl 1,6-diazaspiro[3.3]heptane-6-carboxylate
• CAS: 1272412-72-2
• 化学式: C₁₀H₁₈N₂O₂
• mdl: MFCD18782894
• 分子量: 198.26
• InChiKey: WDVOLHDNUMLNAK-UHFFFAOYSA-N

物化性质

• 沸点：
  282.6±15.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

文献信息

• AZETIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
  申请人：Hoffmann-La Roche Inc.

  公开号：US20130109668A1

  公开（公告）日：2013-05-02

  Provided are compounds of Formula I, R 1 -L 1 -A-L 2 -R 2 (I), and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein A, L 1 , L 2 , R 1 and R 2 are defined herein. The present invention also provides a pharmaceutical composition and methods of using such compounds. The compounds are useful for therapy and/or prophylaxis in a patient, and in particular to inhibitors of Soluble Epoxide Hydrolase (sEH).

  提供的是I式化合物， R 1 -L 1 -A-L 2 -R 2 (I)， 以及其立体异构体、互变异构体和药学上可接受的盐，其中A、L 1 、L 2 、R 1 和R 2 在此处被定义。本发明还提供了一种药物组合物和使用这种化合物的方法。这些化合物对于治疗和/或预防患者特别有用，尤其是对可溶性环氧化酶水解酶（sEH）的抑制剂。
• [EN] AZETIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE<br/>[FR] COMPOSÉS D'AZÉTIDINE, COMPOSITIONS ET LEUR UTILISATION COMME INHIBITEURS DE L'ÉPOXYDE HYDROLASE SOLUBLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013064467A1

  公开（公告）日：2013-05-10

  Provided are compounds of Formula I, stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein A, L1, L2, R1 and R2 are defined herein, a pharmaceutical composition and methods of using such compounds as soluble epoxide hydrolase inhibitors. R1-L1-A-L2-R2

  提供的是式I的化合物，其立体异构体，互变异构体和药学上可接受的盐，其中A，L1，L2，R1和R2在此处定义，一种制药组合物和使用这些化合物作为可溶性环氧化酶抑制剂的方法。R1-L1-A-L2-R2
• COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT
  申请人：GILEAD SCIENCES, INC.

  公开号：US20130273037A1

  公开（公告）日：2013-10-17

  Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

  提供用于治疗病毒感染的化合物、药用可接受的盐和酯及其组合物。这些化合物和组合物对于治疗Pneumovirinae病毒感染很有用。提供的化合物、组合物和方法特别适用于治疗人类呼吸道合胞病毒感染。
• [EN] NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES<br/>[FR] COMPOSÉS TRICYCLIQUES INNOVANTS SERVANT D'INHIBITEURS D'ENZYMES IDH MUTANTES
  申请人：MERCK SHARP & DOHME

  公开号：WO2016089797A1

  公开（公告）日：2016-06-09

  The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

  本发明涉及式(I)的三环化合物，该化合物是野生型异柠檬酸脱氢酶（IDH）抑制剂：(I)。本发明还涉及将此处描述的三环化合物用于潜在治疗或预防涉及一个或多个突变IDH酶的癌症。本发明还涉及包含这些化合物的组合物。本发明还涉及将这些组合物用于潜在预防或治疗此类癌症。
• [EN] MITOCHONDRIAL TARGETING COMPOUNDS FOR THE TREATMENT OF ASSOCIATED DISEASES<br/>[FR] COMPOSÉS DE CIBLAGE MITOCHONDRIAL POUR LE TRAITEMENT DE MALADIES ASSOCIÉES
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2021242753A1

  公开（公告）日：2021-12-02

  Mitochondrial targeting compounds for the treatment of cancer and other disorders associated with mitochondrial function, including diabetes, autoimmune diseases, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases and their preparation. The present invention is also directed to the pharmaceutical compositions and treatment methods, prodrugs based on those compounds and the use thereof.

  针对线粒体功能的癌症和其他疾病的治疗线粒体靶向化合物，包括糖尿病，自身免疫疾病，炎症性疾病，心血管疾病和神经退行性疾病及其制备方法。本发明还涉及基于这些化合物的药物组合物、治疗方法、前药及其用途。