叔-丁基3-(异丙基氨基)吖丁啶-1-甲酸基酯 | 1033716-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 中文名称: 叔-丁基3-(异丙基氨基)吖丁啶-1-甲酸基酯
• 英文名称: tert-butyl 3-(isopropylamino)azetidine-1-carboxylate
• 英文别名: tert-Butyl 3-[(propan-2-yl)amino]azetidine-1-carboxylate；tert-butyl 3-(propan-2-ylamino)azetidine-1-carboxylate
• CAS: 1033716-68-5
• 化学式: C₁₁H₂₂N₂O₂
• mdl: MFCD11520620
• 分子量: 214.308
• InChiKey: DRLGAXOTTPDTQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• ANTIPROLIFERATION COMPOUNDS AND USES THEREOF
  申请人：Merck Patent GmbH

  公开号：US20190322658A1

  公开（公告）日：2019-10-24

  The present invention provides compounds of Formula I′, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

  本发明提供了式I′的化合物，或其药学上可接受的盐，以及用于治疗细胞增殖性疾病（例如癌症）的药物组合物和使用方法。
• TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A BENZOTRIAZOLE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20190055243A1

  公开（公告）日：2019-02-21

  Compounds having a structure according to formula (I) where R 1 , R 2 , and R 3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

  具有如下式(I)所示结构的化合物，其中R1、R2和R3如本文所定义，是Toll样受体7（TLR7）的激动剂，可用作刺激免疫系统的佐剂。其中一些化合物可用于与靶向递送到预期行动的器官或组织的共轭物中。
• Imidazothiazole derivatives
  申请人：Kawato Haruko

  公开号：US20090312310A1

  公开（公告）日：2009-12-17

  There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity: wherein R 1 , R 2 , R 3 , R 4 , and R 5 in the formula (1) each has the same meaning as defined in the specification.

  提供了一种新的化合物，它抑制小鼠双分子分钟2（Mdm2）蛋白与p53蛋白之间的相互作用，并展现出抗肿瘤活性。本发明提供了一种咪唑噻唑衍生物，其表示为以下公式（1），具有各种取代基，可抑制Mdm2蛋白与p53蛋白之间的相互作用并展现出抗肿瘤活性：其中，公式（1）中的R1、R2、R3、R4和R5每个都具有规范中定义的相同含义。
• Benzodiazepine Bromodomain Inhibitor
  申请人：Bailey James

  公开号：US20120252781A1

  公开（公告）日：2012-10-04

  Benzodiazepine compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

  公式（I）的苯二氮平化合物及其盐，含有这种化合物的制药组合物以及它们在治疗中的使用。
• Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10472361B2

  公开（公告）日：2019-11-12

  Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

  具有式(I)结构的化合物 其中 R1、R2 和 R3 如本文所定义，是 Toll 样受体 7 (TLR7) 的激动剂，可用作刺激免疫系统的佐剂。一些此类化合物可用于共轭物，以定向递送至预期作用的器官或组织。