Synthesis of Alcohols from <i>m</i>-Fluorophenylsulfones and Dialkylboranes: Application to the C14–C35 Building Block of E7389
作者:Lei Liu、James A. Henderson、Akihiko Yamamoto、Paul Brémond、Yoshito Kishi
DOI:10.1021/ol300672q
日期:2012.5.4
hydroperoxide oxidation, yields alcohols in high yields. Optimization of the process, scope and limitation, and application to the synthesis of one of the C14–C35 building blocks of E7389, a right half analogue of halichondrin B, are reported.
的反应米-fluorophenylsulfone阴离子与dialkylboranes,随后碱性过氧化氢的氧化,以高收率收率醇。据报道,该方法的工艺,范围和局限性得到优化,并被用于合成E7389的一种C14–C35构建基块,这是葫芦素B的右半类似物。