1-(1,2-二甲氧基丙基)-4-甲氧基苯 | 138169-72-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(1,2-二甲氧基丙基)-4-甲氧基苯
• 英文名称: 1-(4-methoxyphenyl)-1,2-dimethoxypropane
• 英文别名: 1-(1,2-Dimethoxypropyl)-4-methoxybenzene
• CAS: 138169-72-9
• 化学式: C₁₂H₁₈O₃
• 分子量: 210.273
• InChiKey: KAJLCSYJNNSSHC-UHFFFAOYSA-N

物化性质

• 沸点：
  267.8±30.0 °C(Predicted)
• 密度：
  1.003±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(1,2-二甲氧基丙基)-4-甲氧基苯 在 dioxide titanium 氧气 、 silver sulfate 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以93%的产率得到4-甲氧基苯甲酸甲酯
  参考文献：
  名称：

  Photo-oxidative Fragmentation of Some alpha-Alkyl Substituted 4-Methoxybenzyl Alcohols and Methyl Ethers Sensitized by TiO2.

  摘要：

  The TiO2-catalyzed photo-oxidation of some alpha-alkyl substituted 4-methoxybenzyl alcohols and ethers [4-MeOPhCH(OR)Y] has been investigated in MeCN, in the presence of Ag2SO4. When Y=t-Bu, the intermediate radical cation undergoes exclusive C-alpha-H bond cleavage (leading to the corresponding ketone) if R = Me, but predominantly C-alpha-C-beta bond cleavage (leading to 4-MeOPhCHO) if R=H. The C-alpha-H bond cleavage path is also the major one when Y= i-Pr and R=H. For the substrates where Y=CH(OMe)Me or CH(OH)Me, exclusive C-C bond cleavage is observed when R is either H or Me. A similar situation holds when the photo-oxidations are carried out in the presence of oxygen, however a change in the outcome of the reaction has been observed for the substrates where R=Me and Y=t-Bu or CH(OMe)Me, which both form 4-MeOC6H4CO2Me as the exclusive product. These results are interpreted on the basis of the structural effects on the fragmentation reactions of the intermediate radical cations, the stability of the formed carbon radicals and carbocations, as well as the possible reactions of the former with oxygen.

  DOI：

  10.3891/acta.chem.scand.52-0160
• 作为产物：
  描述：

  甲醇 、 茴香烯 在 HgO*HBF₄ 作用下， 反应 4.0h， 以90%的产率得到1-(1,2-二甲氧基丙基)-4-甲氧基苯
  参考文献：
  名称：

  Mercury(II) oxide/tetrafluoroboric acid-promoted vicinal hydroxy- and alkoxylation of alkenes

  摘要：

  DOI：

  10.1016/s0040-4020(01)83510-9

文献信息

• Electrochemical cleavage of the double bond of 1-alkenylarenes
  作者：Yu. N. Ogibin、A. B. Sokolov、A. I. Ilovaiskii、M. N. �linson、G. I. Nikishin

  DOI：10.1007/bf00957996

  日期：1991.3

  A study has been made of the electrochemical cleavage of the double bond of propenylbenzene (Ia) and p-propenylanisole (Ib), which takes place upon anodic oxidation of (Ia, b) in alcoholic solutions of sodium trifluoroacetate and other electrolytes and which leads to conversion of (Ia, b) to benzaldehyde dialkylacetals. Conditions are found that provide for highly selective (> 80%) conversion of (Ib) and p-propenyltoluene to p-methyl- and p-methoxybenzaldehyde dimethylacetals.
• Electrochemical methoxylation of allyl and propenyl derivatives of phenol and phenol ethers
  作者：Isidoro Barba、Rafael Chinchilla、Cecilia Gomez

  DOI：10.1021/jo00297a051

  日期：1990.5
• BARBA, ISIDORO;CHINCHILLA, RAFAEL;GOMEZ, CECILIA, J. ORG. CHEM., 55,(1990) N0, C. 3270-3272
  作者：BARBA, ISIDORO、CHINCHILLA, RAFAEL、GOMEZ, CECILIA

  DOI：——

  日期：——
• BARLUENGA, J.;ALONSO-CIRES, L.;CAMPOS, P. J.;ASENSIO, G., TETRAHEDRON, 1984, 40, N 13, 2563-2568
  作者：BARLUENGA, J.、ALONSO-CIRES, L.、CAMPOS, P. J.、ASENSIO, G.

  DOI：——

  日期：——
• Mercury(II) oxide/tetrafluoroboric acid-promoted vicinal hydroxy- and alkoxylation of alkenes
  作者：José Barluenga、Luisa Alonso-Cires、Pedro J. Campos、Gregorio Asensio

  DOI：10.1016/s0040-4020(01)83510-9

  日期：1984.1