1-(1-甲基-1,2-二氢-3-吡啶基)乙酮 | 100281-00-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-(1-甲基-1,2-二氢-3-吡啶基)乙酮
• 英文名称: 1-(1-Methyl-1,2-dihydro-pyridin-3-yl)-ethanone
• 英文别名: Ethanone, 1-(1,2-dihydro-1-methyl-3-pyridinyl)-(9CI)；1-(1-methyl-2H-pyridin-3-yl)ethanone
• CAS: 100281-00-3
• 化学式: C₈H₁₁NO
• 分子量: 137.181
• InChiKey: LUQZJSNTEIVUHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-acetyl-1-methylpyridinium iodide 以40%的产率得到
  参考文献：
  名称：

  BARTON, D. H. R.;FEKIH, ABDELWAHEB;LUSINCHI, XAVIER, TETRAHEDRON LETT., 1985, 26, N 31, 3693-3696

  摘要：

  DOI：

文献信息

• Drug delivery from rapid gelling polymer composition
  申请人：ANGIOTECH INTERNATIONAL AG

  公开号：EP2181704A2

  公开（公告）日：2010-05-05

  Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in prevention of surgical adhesions.

  本发明公开了一些组合物，这些组合物由两部分聚合物组成，在混合在一起时可迅速形成共价连接，从而实现药物输送。当需要快速粘附组织和形成凝胶并同时给药时，这种组合物特别适合用于各种与组织相关的应用。例如，这种组合物可用作组织密封剂、促进止血、实现组织粘合、提供组织增量以及防止手术粘连。
• Selective reduction of imonium salts by sodium hydrogen telluride
  作者：Derek H.R. Barton、Abdelwaheb Fekih、Xavier Lusinchi

  DOI：10.1016/s0040-4039(00)89225-4

  日期：1985.1
• THE USE OF N-METHYL PYRIDINIUM DERIVATIVES FOR HEPATOPROTECTION
  申请人：Hependo Sp. z.o.o.

  公开号：EP2124946B1

  公开（公告）日：2012-05-23
• NICOTINAMIDE COMPOSITIONS FOR TREATMENT OF SKIN DISEASES AND DISORDERS
  申请人：Gebicki Jerzy

  公开号：US20080112968A1

  公开（公告）日：2008-05-15

  The present invention is directed to compositions of nicotinamide derivatives combined with wakame seaweed, wakame extracts, or glycosaminoglycans, and their use in treating skin diseases and disorders.
• Use of Quaternary Pyridinium Compounds for Vasoprotection and/or Hepatoprotection
  申请人：MARCINEK Andrzej

  公开号：US20110118316A1

  公开（公告）日：2011-05-19

  The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of: wherein R represents hydrogen atom, CH 3 , OH, pyridyl (C 5 H 4 N), 1-methylpyridyl (C 5 H 4 N—CH 3 ) or pyridyl substituted with hydroxy group ((OH)C 5 H 3 N), and X represents a physiologically acceptable counterion.