1-(2,2-二甲氧基乙氧基)癸烷 | 6947-36-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2,2-二甲氧基乙氧基)癸烷
• 英文名称: N-nitrosodi(anisyl)amine
• 英文别名: bis-(4-methoxy-phenyl)-nitroso-amine；Bis-(4-methoxy-phenyl)-nitroso-amin；N-Nitroso-4.4'-dimethoxy-diphenylamin；Bis-(4-methoxy-phenyl)-nitrosamin；Bis-<4-methoxy-phenyl>-nitrosamin；N-Nitroso-bis--amin；N,N-bis(4-methoxyphenyl)nitrous amide
• CAS: 6947-36-0
• 化学式: C₁₄H₁₄N₂O₃
• 分子量: 258.277
• InChiKey: LFYGAGWUDURWIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(2,2-二甲氧基乙氧基)癸烷 在 乙醇 、 溶剂黄146 、 锌 作用下， 生成 1,1-bis(p-anisyl)hydrazine
  参考文献：
  名称：

  Wieland, Chemische Berichte, 1908, vol. 41, p. 3486

  摘要：

  DOI：
• 作为产物：
  描述：

  4'-甲氧基乙酰苯胺 在 盐酸 、 乙醇 、 水 、 碘 、 铜 、 potassium carbonate 、 硝基苯 、 sodium nitrite 作用下， 生成 1-(2,2-二甲氧基乙氧基)癸烷
  参考文献：
  名称：

  Wieland, Chemische Berichte, 1908, vol. 41, p. 3486

  摘要：

  DOI：

文献信息

• Mechanochemistry for Healthcare: Revealing the Nitroso Derivatives Genesis in the Solid State
  作者：Francesco Basoccu、Federico Cuccu、Andrea Porcheddu

  DOI：10.1002/cssc.202301034

  日期：2024.2.8

  Nitroso derivatives with unique characteristics have been extensively studied in various fields, including biology and clinical research. Although there has been substantial investigation of “nitrosable” components in many drugs and commonly consumed nutrients, there is still a need for a higher awareness about their formation and characterization. This study demonstrates how these derivatives can be produced through a mechanochemical procedure under solid‐state conditions. The results include synthesizing previously unknown compounds with potential biological and pharmaceutical applications, such as a nitrosamine derived from a Diclofenac‐like structure.

  摘要 具有独特特征的亚硝基衍生物已在生物学和临床研究等多个领域得到广泛研究。尽管人们对许多药物和常见营养素中的 "亚硝基 "成分进行了大量研究，但对其形成和特征的认识仍有待提高。本研究展示了如何在固态条件下通过机械化学程序生产这些衍生物。研究结果包括合成了以前未知的、具有潜在生物和医药应用价值的化合物，例如从类似双氯芬酸结构中衍生出的亚硝胺。
• Wieland; Lecher, Justus Liebigs Annalen der Chemie, 1912, vol. 392, p. 165
  作者：Wieland、Lecher

  DOI：——

  日期：——
• Groups 5 and 6 Terminal Hydrazido(2−) Complexes: N_β Substituent Effects on Ligand-to-Metal Charge-Transfer Energies and Oxidation States
  作者：Ian A. Tonks、Alec C. Durrell、Harry B. Gray、John E. Bercaw

  DOI：10.1021/ja302275j

  日期：2012.5.2

  Brightly colored terminal hydrazido(2-) (dme)MCl3(NNR2) (dme = 1,2-dimethoxyethane; M = Nb, Ta; R = alkyl, aryl) or (MeCN)WCl4(NNR2) complexes have been synthesized and characterized. Perturbing the electronic environment of the beta (NR2) nitrogen affects the energy of the lowest-energy charge-transfer (CT) transition in these complexes. For group 5 complexes, increasing the energy of the N-beta lone pair decreases the ligand-to-metal CT (LMCT) energy, except for electron-rich niobium diallcylhydrazides, which pyramidalize N-beta in order to reduce the overlap between the Nb=N-alpha pi bond and the N-beta lone pair. For W complexes, increasing the energy of N-beta eventually leads to reduction from formally [W-VI N-NR2] with a hydraziclo(2-) ligand to [W-IV=N=NR2] with a neutral 1,1-diazene ligand. The photophysical properties of these complexes highlight the potential redox noninnocence of hydrazido ligands, which could lead to ligand- and/or metal-based redox chemistry in early transition metal derivatives.
• Wieland, Justus Liebigs Annalen der Chemie, 1911, vol. 381, p. 206
  作者：Wieland

  DOI：——

  日期：——
• Koshechko, V. G.; Inozemtsev, A. N.; Pokhodenko, V. D., Journal of Organic Chemistry USSR (English Translation), 1983, vol. 19, # 4, p. 662 - 666
  作者：Koshechko, V. G.、Inozemtsev, A. N.、Pokhodenko, V. D.

  DOI：——

  日期：——