暗褐菌素 | 83-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 中文名称: 暗褐菌素
• 英文名称: fuscin
• 英文别名: 5-hydroxy-4,8,8-trimethyl-9,10-dihydro-4H-pyrano[4,3-f]chromene-2,6-dione
• CAS: 83-85-2
• 化学式: C₁₅H₁₆O₅
• 分子量: 276.289
• InChiKey: OSJKAGRXDVEZQO-UHFFFAOYSA-N

物化性质

• 熔点：
  230℃
• 沸点：
  511.1±50.0 °C(Predicted)
• 密度：
  1.35±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  暗褐菌素 在 sodium dithionite 作用下， 生成 dihydrofuscin
  参考文献：
  名称：

  从三个新的异色满-3-酮代谢物隔离Oidiodendron rhodogenum Robak

  摘要：

  真菌Oidiodendron rhodogenum Robak产生curvulinic酸，fuscin，并且这些结构为其中（3）三个新的异苯并二氢吡喃-3-酮的代谢物-被提出（5）。在相同条件下生长的第二个菌株产生融合蛋白和二氢融合蛋白。

  DOI：

  10.1039/p19810000221
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 、 乙醇 、 碳酸氢钠 作用下， 生成 暗褐菌素
  参考文献：
  名称：

  213.岩藻糖素的组成与合成

  摘要：

  DOI：

  10.1039/jr9560001028

文献信息

• Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：EP1097942A2

  公开（公告）日：2001-05-09

  This invention provides a monoclonal antibody capable of binding to a protein which is specifically recognized by monoclonal antibody 5c8 produced by the hybridoma having ATCC Accession No. HB 10916. This invention also provides an isolated protein which is specifically recognized by monoclonal antibody 5c8 produced by the hybridoma having ATCC Accession No. HB 10916. This invention further provides an isolated nucleic acid molecule encoding a protein which is specifically recognized by monoclonal antibody 5c8 produced by the hybridoma having ATCC No. HB 10916. This invention also provides a human CD4- T cell leukemia cell line designated D1.1 having ATCC Accession No. CRL 10915 capable of constitutively providing cotnact-dependent helper function to B cells.

  本发明提供了一种单克隆抗体，它能与一种蛋白质结合，该蛋白质能被ATCC登录号为HB 10916的杂交瘤产生的单克隆抗体5c8特异性识别。本发明还提供了一种分离的蛋白质，它能被具有 ATCC 编号 HB 10916 的杂交瘤产生的单克隆抗体 5c8 特异性识别。本发明进一步提供了一种分离的核酸分子，该核酸分子编码的蛋白质可被具有 ATCC 编号 HB 10916 的杂交瘤产生的单克隆抗体 5c8 特异性识别。本发明还提供了一种人CD4-T细胞白血病细胞系，命名为D1.1，其ATCC登录号为CRL 10915，能够组成性地向B细胞提供依赖于同工酶的辅助功能。
• Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
  申请人：Proteotech Inc.

  公开号：EP1808169A2

  公开（公告）日：2007-07-18

  Polyhydroxylated aromatic compounds, and compositions containing them, are useful for the treatment of amyloidosis, especially Alzheimer's disease, and for the treatment of diseases characterized by α-synuclein fibril formation, especially Lewy body disease and Parkinson's disease.

  多羟基芳香族化合物和含有它们的组合物可用于治疗淀粉样变性病，特别是阿尔茨海默病，以及治疗以α-突触核蛋白纤维形成为特征的疾病，特别是路易体病和帕金森病。
• Hair dye
  申请人：Shiseido Company, Ltd.

  公开号：US11191711B2

  公开（公告）日：2021-12-07

  A hair dye that is safe for human bodies and has a high hair dyeing effect is provided. The hair dye consisting of: a reaction solution (A) comprising: a substance having a specific flavonoid skeleton represented by the following general formula (1); one type or two or more types selected from benzyl alcohol, vanillin, propylene carbonate, and γ-butyrolactone; and one type or two or more types selected from a thioglycolic acid salt, a thiolactic acid salt, cysteine and cysteamine, and a reaction solution (B) comprising an oxidizing agent. (In the formula, R1, R2, R3, R4, R6, and R7 independently represent a hydrogen atom, a hydroxy group, or a methyl group; either one or both of R6 and R7 is/are a hydroxy group; R5 represents a hydrogen atom, a hydroxy group, a galloyl group, or a saccharide; and X represents >CH2, >C═O, or >CHOH.)

  提供一种对人体安全、染发效果好的染发剂。 该染发剂包括： 反应溶液 (A)，包括：具有由以下通式 (1) 表示的特定黄酮类骨架的物质；一种或两种或两种以上选自苯甲醇、香兰素、碳酸丙烯酯和γ-丁内酯的物质；一种或两种或两种以上选自硫代乙醇酸盐、硫代乳酸盐、半胱氨酸和半胱胺的物质，以及 包含氧化剂的反应溶液 (B)。 (式中，R1、R2、R3、R4、R6 和 R7 分别代表氢原子、羟基或甲基；R6 和 R7 中的一个或两个是/是羟基；R5 代表氢原子、羟基、戊酰基或糖基；X 代表 >CH2、>C═O 或 >CHOH)。
• Murine monoclonal antibody (5c8) recognizes T-B cell activating molecule (T-BAM) (CD40 LIGAND) on the surface of T-lymphocytes, compositions containing same and methods of use
  申请人：Lederman Seth

  公开号：US20060110392A1

  公开（公告）日：2006-05-25

  The present invention provides a monoclonal antibody capable of binding to a protein which is specifically recognized by monoclonal antibody 5c8 produced by the hybridoma having ATCC Accession No. HB 10916. This invention also provides compositions comprising the antibody, and hybridomas that produce the antibody. This invention also provides an isolated protein which is specifically recognized by monoclonal antibody 5c8 produced by the hybridoma having ATCC Accession No. HB 10916.

  本发明提供了一种单克隆抗体，该抗体能够与一种蛋白质结合，该蛋白质被ATCC登录号为HB 10916的杂交瘤产生的单克隆抗体5c8特异性识别。本发明还提供了包含该抗体的组合物以及产生该抗体的杂交瘤。本发明还提供了一种分离蛋白，该蛋白可被 ATCC登录号为 HB 10916 的杂交瘤产生的单克隆抗体 5c8 特异性识别。
• Birkinshaw et al., Biochemical Journal, 1951, vol. 48, p. 67,73
  作者：Birkinshaw et al.

  DOI：——

  日期：——