LY 310214

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: LY 310214
• 英文别名: (2R,4S)-2-allyl-4-aminopentanedioic acid；(2S,4R)-2-amino-4-prop-2-enylpentanedioic acid
• 化学式: C₈H₁₃NO₄
• 分子量: 187.196
• InChiKey: APFSBOCBNKHACW-RITPCOANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2S,4R)-2-Allyl-4-tert-butoxycarbonylamino-pentanedioic acid 在 三氟乙酸 作用下， 以 乙醚 为溶剂， 反应 4.0h， 生成 LY 310214
  参考文献：
  名称：

  4-烷基-和4-肉桂基谷氨酸类似物是有效的GluR5海藻酸酯受体激动剂。

  摘要：

  制备对映体纯的（2S，4R）-4-取代的谷氨酸，并测试其同质的GluR5和GluR6海藻酸酯亚型受体亲和力。一些4-肉桂基类似物对GluR5受体显示出高选择性和强效性（K（i）<25 nM）。用3-（2-萘基）丙-2-烯基化合物获得最大的选择性和效力。该化合物LY339434对AMPA和红藻氨酸受体GluR1，-2，-4和-6的活性可忽略不计。虽然，LY339434在文化海马神经元（大约EC（50）为2.5 microM）对NMDA受体显示激动剂活性，我们认为LY339434应该是研究GluR5海藻酸酯受体功能作用的有用药理工具。

  DOI：

  10.1021/jm9911682

文献信息

• Photoreactive regulator of protein function and methods of use thereof
  申请人：Isacoff Y. Ehud

  公开号：US20070128662A1

  公开（公告）日：2007-06-07

  The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
• Photoreactive Regulator of Protein Function and Methods of Use Thereof
  申请人：ISACOFF EHUD Y.

  公开号：US20120190094A1

  公开（公告）日：2012-07-26

  The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
• PHOTOREACTIVE REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：US20150224193A1

  公开（公告）日：2015-08-13

  The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
• US8114843B2
  申请人：——

  公开号：US8114843B2

  公开（公告）日：2012-02-14
• US8309350B2
  申请人：——

  公开号：US8309350B2

  公开（公告）日：2012-11-13