1-(2-乙烯基苯基)-1-丙醇 | 350248-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2-乙烯基苯基)-1-丙醇
• 英文名称: 1-(2-vinylphenyl)-1-propanol
• 英文别名: 1-(2-Ethenylphenyl)propan-1-ol
• CAS: 350248-52-1
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: HSOHTOBAYQBMOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2906299090

反应信息

• 作为反应物：
  描述：

  1-(2-乙烯基苯基)-1-丙醇 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以69%的产率得到1-(2-vinylphenyl)propan-1-one
  参考文献：
  名称：

  通过 C–C 激活启用烯烃的 1,1-插入无应变酮的分子内单碳同系化

  摘要：

  在这里，我们描述了通过烯烃的正式 1,1-插入过程，通过临时导向基团 (TDG) 辅助的 C-C 活化实现的 Rh 催化的无应变芳基酮的分子内单碳同系化的发展。该反应提供了一种独特的方法来获得各种取代的 1-茚满酮。计算机理研究表明，正式的 1,1-插入是通过选择性 C(sp 2 )–C(sp 3 ) 激活和限制 2,1-插入烯烃的转换来实现的，然后是轻松的 β-H 消除和重新插入过程。

  DOI：

  10.1021/acs.orglett.2c00716
• 作为产物：
  描述：

  magnesium,ethenylbenzene,bromide 、 丙醛 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 1-(2-乙烯基苯基)-1-丙醇
  参考文献：
  名称：

  Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants

  摘要：

  Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series, 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.

  DOI：

  10.1016/0223-5234(96)88213-4

文献信息

• POLYPHENYLENE ETHER RESIN COMPOSITION
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0765914A1

  公开（公告）日：1997-04-02

  A polyphenylene ether resin composition containing the following Components (A) to (D) according at the following formulation ratio. (A) 50 to 99.5 parts by weight of a polyphenylene ether (B) 0.1 to 50 parts by weight of a partially hydrogenated aromatic alkenyl compound-conjugated diene block copolymer having a hydroxy group and based on 100 parts by weight of the above resin composition, (C) 0 to 950 parts by weight of a thermoplastic resin and (D) 0 to 10 parts by weight of a phosphorous acid triester

  一种聚苯醚树脂组合物，按以下配比含有以下成分（A）至（D）。 (A) 50 至 99.5 重量份的聚苯醚 (B) 0.1 至 50 份（按重量计）具有羟基的部分氢化芳香族烯基化合物-共轭 二烯嵌段共聚物 以上述树脂组合物 100 份重量计、 (C) 0 至 950 重量份的热塑性树脂 和 (D) 0 至 10 份(重量)的磷酸三酯
• Selective Halogen−Magnesium Exchange Reaction via Organomagnesium Ate Complex
  作者：Atsushi Inoue、Kazuya Kitagawa、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1021/jo015597v

  日期：2001.6.1

  Halogen-magnesium exchange of various aryl halides is achieved with a magnesium ate complex at low temperatures; Tributylmagnesate ((Bu3MgLi)-Bu-n) induces facile iodine-magnesium exchange at -78 degreesC. Dibutylisopropylmagnesate ((PrBu2MgLi)-Pr-i-Bu-n) is more reactive than (Bu3MgLi)-Bu-n, and this reagent accomplishes selective bromine-magnesium exchange at -78 degreesC. This procedure is utilized for the preparation of various polyfunctionalized arylmagnesium species. The exchange of alkenyl halides using this method proceeds with retention of configuration of the double bond.
• TERMINALLY UNSATURATED MACROMOLECULAR MONOMERS OF POLYFORMALS AND COPOLYMERS THEREOF
  申请人：The B.F. Goodrich Company

  公开号：EP0357691A1

  公开（公告）日：1990-03-14
• EP0357691A4
  申请人：——

  公开号：EP0357691A4

  公开（公告）日：1992-03-18
• PEG-BASED MACROMONOMERS, CHEMICALLY INERT POLYMERS PREPARED THEREFROM AND THE USE OF THESE POLYMERS FOR ORGANIC SYNTHESIS AND ENZYME REACTIONS
  申请人：Carlsberg A/S

  公开号：EP1137690A2

  公开（公告）日：2001-10-04