(2E,4E,6E)-15-hydroxyicosa-2,4,6-trienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2E,4E,6E)-15-hydroxyicosa-2,4,6-trienoic acid
• 化学式: C₂₀H₃₄O₃
• 分子量: 322.5
• InChiKey: FPMGOQWJNUZGTC-KPQBNAFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Lipid-amino acid conjugates and methods of use
  申请人：Burstein H. Sumner

  公开号：US20060014820A1

  公开（公告）日：2006-01-19

  N-fatty acid-amino acid conjugates and J 2 prostanoid-amino acid conjugates are disclosed along with methods for making such conjugates and methods of using these conjugates in the treatment of conditions that involve dysfunctional lipid metabolism, insulin sensitivity, glucose homeostasis, and/or inflammation.

  N-脂肪酸-氨基酸共轭物和J2前列腺素-氨基酸共轭物被披露，以及制备这些共轭物的方法和在治疗涉及异常脂质代谢、胰岛素敏感性、葡萄糖稳态和/或炎症的疾病中使用这些共轭物的方法。
• METHODS OF MAKING 15-HYDROXY FATTY ACID DERIVATIVES
  申请人：Dignity Sciences Limited

  公开号：US20150119593A1

  公开（公告）日：2015-04-30

  The present disclosure provides methods of making 15-hydroxy fatty acid derivatives, such as 15-(S)-hydroxyeicosatrienoic acid (HETrE or 15-(S)-HETrE) or 15(S)-hydroxyeicosapentaenoic acid (HEPE or 15(S)-HEPE) from the corresponding fatty acid (e.g., dihomo-γ-linolenic acid (DGLA) or eicosapentaenoic acid (EPA), respectively). In some embodiments, the method comprises contacting the fatty acid with an oxidizing agent (e.g., a lipoxygenase and oxygen) in the presence of a reducing agent (e.g., cysteine) to form the 15-hydroxy fatty acid derivatives in a single reaction vessel.

  本公开提供制备15-羟基脂肪酸衍生物的方法，例如制备15-(S)-羟基二十碳三烯酸（HETrE或15-(S)-HETrE）或15(S)-羟基二十碳五烯酸（HEPE或15(S)-HEPE）从相应的脂肪酸（例如二十二碳六烯酸（DGLA）或二十碳五烯酸（EPA））。在某些实施例中，该方法包括在单个反应容器中将脂肪酸与氧化剂（例如脂肪酸过氧化酶和氧气）在还原剂（例如半胱氨酸）的存在下接触，以形成15-羟基脂肪酸衍生物。
• COMPOSITION CONTAINING DIHOMO-(gamma)-LINOLENIC ACID (DGLA) AS THE ACTIVE INGREDIENT
  申请人：SUNTORY LIMITED

  公开号：EP1852114A1

  公开（公告）日：2007-11-07

  The present invention provides a composition, such as a food and pharmaceutical agent, which comprises dihomo-γ-linolenic acid, and which has the effect of preventing or treating skin diseases; a composition such as a food and pharmaceutical agent which comprises dihomo-γ-linolenic acid and which has the effect of preventing or treating skin diseases; and a composition which comprises dihomo-γ-linolenic acid and which has the effect of preventing or treating diseases related to increased mast cell count.

  本发明提供了一种包含二氢-γ-亚麻酸的组合物（如食品和药物制剂），该组合物具有预防或治疗皮肤病的功效；一种包含二氢-γ-亚麻酸的组合物（如食品和药物制剂），该组合物具有预防或治疗皮肤病的功效；以及一种包含二氢-γ-亚麻酸的组合物，该组合物具有预防或治疗与肥大细胞数量增加有关的疾病的功效。
• COMPOSITION FOR EXTERNAL SKIN USE FOR INFLAMMATORY DISEASES
  申请人：Nippon Suisan Kaisha, Ltd.

  公开号：EP2708230A1

  公开（公告）日：2014-03-19

  [Problem] Provision of a composition for external use on skin that is safe to use and has an anti-inflammatory and anti-allergic actions. [Solution] A composition for external use on skin in the treatment of inflammatory disease which comprises dihomo-γ-linolenic acid (DGLA) as an active ingredient. The DGLA is preferably contained as a glyceride, a phospholipid, or an alkyl ester. The composition for external use contains DGLA in an amount of 0.1-50 wt%.

  [问题] 提供一种使用安全、具有抗炎和抗过敏作用的皮肤外用组合物。[解决方案]一种用于治疗炎症疾病的皮肤外用组合物，其中包含作为活性成分的二氢-γ-亚麻酸（DGLA）。DGLA 最好以甘油酯、磷脂或烷基酯的形式存在。外用组合物中 DGLA 的含量为 0.1-50 wt%。
• Pharmaceutical compositions comprising DGLA and use of same
  申请人：DS Biopharma Limited

  公开号：US10105333B2

  公开（公告）日：2018-10-23

  The present disclosure provides orally deliverable pharmaceutical compositions comprising DGLA and to methods of using same to treat a variety of conditions and disorders.

  本公开提供了包含 DGLA 的可口服给药组合物，以及使用该组合物治疗各种疾病的方法。