1-(2-硝基-4,5-二甲氧基苯基)-N,N,N',N'-四((氧羰基)甲基)-1,2-乙二胺 | 117367-86-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-(2-硝基-4,5-二甲氧基苯基)-N,N,N',N'-四((氧羰基)甲基)-1,2-乙二胺
• 英文名称: DM-Nitrophen
• 英文别名: 2-[[2-[bis(carboxymethyl)amino]-2-(4,5-dimethoxy-2-nitrophenyl)ethyl]-(carboxymethyl)amino]acetic acid
• CAS: 117367-86-9
• 化学式: C18H23N3O12
• 分子量: 473.4
• InChiKey: FKXGYESXGMKAKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  220
• 氢给体数：
  4
• 氢受体数：
  14

文献信息

• Super-resolution sequencing
  申请人：Mir Kalim U.

  公开号：US11066701B2

  公开（公告）日：2021-07-20

  A method for template-directed sequencing-by-synthesis of an array of target polynucleotide can include: (a) providing an array of target polynucleotides in a fluidic vessel; (b) contacting the array of polynucleotides with a solution comprising (i) polymerization complex and (ii) reversibly terminating and differently labeled A,C,G, and T/U nucleotides; (c) incorporating one of the differently labeled nucleotides, using the polymerization complex, into a chain complementary to at least one of the array of polynucleotides; (d) binding imaging tags to the differently labeled nucleotides of step (c); (e) imaging and storing the identity and position of the imaging tags of step (d); (f) reversing termination (b)-(e); (g) repeating steps (b)-(e) and assembling a sequence for each of the array of target polynucleotides from the stored identity and position of the imaging tags, optionally as a homogeneous or one pot reaction. Additional methods of sequencing target polynucleotides are described herein.

  通过合成对目标多核苷酸阵列进行模板定向测序的方法可包括 (a) 在流体容器中提供目标多核苷酸阵列； (b) 将多核苷酸阵列与溶液接触，溶液包括：(i) 聚合复合物；(ii) 可逆终止和不同标记的 A、C、G 和 T/U 核苷酸； (c) 使用聚合复合物将其中一种不同标记的核苷酸结合到与多核苷酸阵列中至少一种核苷酸互补的链中； (d) 将成像标签与步骤(c)中不同标记的核苷酸结合； (e) 对步骤(d)的成像标签的身份和位置进行成像和存储； (f) 反转步骤(b)-(e) (g) 重复步骤(b)-(e)，并根据存储的成像标记的身份和位置，为每个目标多核苷酸阵列组装序列，可选择作为均相反应或一锅反应。本文还描述了对目标多核苷酸进行测序的其他方法。
• Caged compound cleaving process
  申请人：——

  公开号：US20040253726A1

  公开（公告）日：2004-12-16

  Caged compounds, i.e. synthetic chemical compounds whose chemical or biochemical activity is normally controlled by photolysis to release an active moiety to participate in a chemical or biochemical reaction, are subjected to electrical current instead of light to release the active moiety. The process is especially useful in chemiluminescent biochemical assays, where it is required to measure the light output in order to quantify the analyte under measurement, since avoids confusion between input energy to trigger the reaction, and light output for measurement purposes.

  笼状化合物，即化学或生化活性通常由光解控制的合成化合物，释放出活性分子参与化学或生化反应。这种工艺在化学发光生化检测中特别有用，因为它避免了引发反应的输入能量与用于测量的光输出之间的混淆。
• CAGED COMPOUND CLEAVING PROCESS
  申请人：Cardiogenics Inc.

  公开号：EP1407264A1

  公开（公告）日：2004-04-14
• SUPER-RESOLUTION SEQUENCING
  申请人：Mir, Kalim U.

  公开号：EP3411494A1

  公开（公告）日：2018-12-12
• METHOD OF CONTROLLED DRUG RELEASE FROM A LIPOSOME CARRIER
  申请人：Fologea Daniel

  公开号：US20120041357A1

  公开（公告）日：2012-02-16

  Disclosed are methods and compositions for the controlled release of a drug or agent from a liposome using light or radiation. Also disclosed are compositions comprising liposomes having a lipid layer, wherein the liposomes contain an agent, an enzyme capable of releasing the agent from the liposome, and an enzyme activator sequestered by a molecular cage. In another aspect, methods of delivering an agent to a target in a subject are disclosed.