1-(3,5-二甲基苯基)-4-甲基-1-环己烯 | 65763-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 中文名称: 1-(3,5-二甲基苯基)-4-甲基-1-环己烯
• 英文名称: N-bromobenzotriazole
• 英文别名: 1-bromo-1H-benzotriazole；1-bromobenzotriazole；1-Brombenzotriazol
• CAS: 65763-68-0
• 化学式: C₆H₄BrN₃
• 分子量: 198.022
• InChiKey: ATJMOAJETHUYOG-UHFFFAOYSA-N

物化性质

• 熔点：
  113-114 °C (decomp)
• 沸点：
  300.4±25.0 °C(Predicted)
• 密度：
  1.89±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  茴香硫醚 、 1-(3,5-二甲基苯基)-4-甲基-1-环己烯 以 乙腈 为溶剂， 以74%的产率得到1-[(苯基硫代)甲基]-1H-苯并三唑
  参考文献：
  名称：

  Direct methyl C(sp³)–H azolation of thioanisoles via oxidative radical coupling

  摘要：

  一种温和的有机催化剂促进的甲基C(sp³)–H键与硫代苯甲醚的氮化反应已被开发出来，为构建氮功能化硫代苯甲醚提供了一种简便的方法。

  DOI：

  10.1039/c9ob01530b
• 作为产物：
  描述：

  1-氯苯并三氮唑 、 溴 以80%的产率得到
  参考文献：
  名称：

  SASSE M. J.; STORR R. C., J. CHEM. SOC. PERKIN TRANS., PART 1, 1978, NO 8, 909-912

  摘要：

  DOI：

文献信息

• [EN] TRIAZOLE FUSED HETEROARYL COMPOUNDS AS P38 KINASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROARYLIQUES FUSIONNÉS DE TRIAZOLE EN TANT QU'INHIBITEURS DE KINASE P38
  申请人：AMGEN INC

  公开号：WO2009038784A1

  公开（公告）日：2009-03-26

  The present invention comprises a new class of compounds useful for modulating the activity of p38 MAP kinase. The compounds have a general Formula (I) wherein A1, A2, A3, A4, A5, A6, R1 and R5 are defined herein. The invention further provides pharmaceutical compositions including one or more compounds of Formula (I), use of such compounds and compositions for treatment of p38 MAP kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula (I).

  本发明涵盖了一类新型化合物，用于调节p38 MAP激酶的活性。这些化合物具有一般的化学式（I），其中A1、A2、A3、A4、A5、A6、R1和R5在此处定义。本发明还提供了包括一种或多种化合物的化学式（I）的药物组合物，以及用于治疗p38 MAP激酶介导的疾病，包括类风湿性关节炎、牛皮癣和其他炎症性疾病的化合物和组合物的用途，以及用于制备化合物的中间体和有用的过程。
• ETHER BENZOTRIAZOLE DERIVATIVES
  申请人：Beshore Douglas C.

  公开号：US20120135977A1

  公开（公告）日：2012-05-31

  The present invention is directed to ether benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及乙醚苯并三唑衍生物，它们是代谢型谷氨酸受体的增效剂，特别是mGluR2受体，对治疗或预防与谷氨酸功能障碍相关的神经系统和精神疾病以及代谢型谷氨酸受体参与的疾病具有用处。该发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗代谢型谷氨酸受体参与的疾病中的使用。
• TRIAZOLE FUSED HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Pettus Liping H.

  公开号：US20100292234A1

  公开（公告）日：2010-11-18

  The present invention comprises a new class of compounds useful for modulating the activity of p38 MAP kinase. The compounds have a general Formula I wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , R 1 and R 5 are defined herein. The invention further provides pharmaceutical compositions including one or more compounds of Formula I, use of such compounds and compositions for treatment of p38 MAP kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

  本发明涉及一种新的化合物类别，用于调节p38 MAP激酶的活性。该化合物具有一般的I式，其中A1、A2、A3、A4、A5、A6、R1和R5如本文所定义。本发明还提供了包括一种或多种I式化合物的制药组合物，使用这种化合物和组合物治疗p38 MAP激酶介导的疾病，包括类风湿性关节炎、牛皮癣和其他炎症性疾病，以及有用于制备I式化合物的中间体和过程。
• Process for the preparation of beta-lactam compounds
  申请人：BEECHAM GROUP PLC

  公开号：EP0112049A1

  公开（公告）日：1984-06-27

  The present invention provides a process for the substitution of an acylamino β-lactam compound at the carbon atom carrying the acylamino group, which process comprises reacting the β-lactam compound with an halogenating agent and a nucleophilic reagent; characterised in that the acylamino group has an acidic group on the carbon atom adjacent the carbonyl group. In particular the process of this invention comprises reacting a β-lactam of partial structure (I): where X represents an acidic group; with an halogenating agent and a nucleophilic reagent.

  本发明提供了一种在携带酰氨基的碳原子上取代酰氨基β-内酰胺化合物的工艺，该工艺包括使β-内酰胺化合物与卤化剂和亲核试剂反应；其特征在于酰氨基在邻近羰基的碳原子上具有酸性基团。 本发明的工艺尤其包括使部分结构为(I)的β-内酰胺反应： 其中 X 代表酸性基团；与卤化剂和亲核试剂反应。
• Silver halide photographic material
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0335319A2

  公开（公告）日：1989-10-04

  A silver halide photographic material composed of a support having thereon at least one silver halide photosensitive emulsion layer, at least one layer of the material containing a blocked photographic reagent precursor represented by formula (I): wherein X1 represents a divalent linking group containing a hetero atom bonded to the carbon atom, provided that X1 is linked to the carbon atom by a group other than PUG represents a photographically useful group containing a hetero atom bonded to X1; W represents = N- or represents hydrogen or a group capaable of being substituted; Z represents an atomic group necessary for forming a heterocyclic ring, provided that when W represents a group, the group adjacent to W in the heterocyclic ring is a group other than wherein R1, R2, R3, R4 and R5 each represents hydrogen or or group capable of being substituted; and m is 0 or 1, with proviso that when m is 0, the photographically useful group represented by PUG is bonded to a carbon atom via heteroatom of PUG. The photographic materials have superior stability during storage, and are capable of releasing a photographic reagent with specifically required timing during processing, and in a wide pH range.

  一种卤化银感光材料，由至少有一层卤化银感光乳剂层的支撑体组成，该材料的至少一层含有由式 (I) 表示的封端感光试剂前体： 其中 X1 代表含有与碳原子键合的杂原子的二价连接基团，但 X1 与碳原子之间的连接基团必须不是 PUG 代表含有与 X1 键合的杂原子的摄影有用基团； W 代表＝N-或 代表氢或可被取代的基团；Z 代表形成杂环所需的原子团，但当 W 代表 当 W 代表一个基团时，杂环中与 W 相邻的基团是一个基团，而不是 其中 R1、R2、R3、R4 和 R5 分别代表氢或可被取代的基团；以及 m 为 0 或 1，但当 m 为 0 时，PUG 所代表的对照片有用的基团通过 PUG 的杂原子与碳原子结合。这种感光材料在贮存过程中具有优异的稳定性，在加工过程中能够按照特定要求的时间释放感光试剂，并且适用于较宽的 pH 值范围。