7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-5-heptenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-5-heptenoic acid
• 英文别名: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoic acid
• 化学式: C₂₃H₂₉F₃O₆
• 分子量: 458.5
• InChiKey: WWSWYXNVCBLWNZ-LELZANKISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Process for the Preparation of Prostaglandin Analogues and Intermediates Thereof
  申请人：Henschke Julian P.

  公开号：US20090259058A1

  公开（公告）日：2009-10-15

  The present application provides intermediates for preparing prostaglandin analogues and processes for preparing prostaglandin analogues and intermediates thereof. The intermediates include: A compound of formula (6): R 1 represents H, C 1 -C 5 -alkyl, or benzyl, in particular isopropyl.

  本申请提供了用于制备前列腺素类似物的中间体以及制备前列腺素类似物和其中间体的方法。这些中间体包括：化合物的公式（6）： R 1 代表H，C 1 -C 5 -烷基，或苄基，特别是异丙基。
• NITRIC OXIDE DONATING DERIVATIVES OF FLUPROSTENOL
  申请人：NICOX S.A.

  公开号：US20180118677A1

  公开（公告）日：2018-05-03

  The present invention relates to 15-nitrooxyderivatives of fluprostenol, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxy derivatives of fluprostenol.

  本发明涉及15-硝氧基丙烯酸氟前列醇衍生物，其用于治疗青光眼和眼压增高，以及含有15-硝氧基丙烯酸氟前列醇衍生物的配方。
• PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
  申请人：CHIROGATE INTERNATIONAL INC.

  公开号：US20150051410A1

  公开（公告）日：2015-02-19

  Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R 2 , R 3 and R 4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

  提供了一种用于制备基本上不含5,6-顺式异构体的化合物I-2的新工艺：其中R2、R3和R4如规范中定义。还提供了用于制备无异构体前列腺素及其衍生物的新中间体。
• PROCESS FOR PREPARATION OF PROSTAGLANDIN F2 ALPHA ANALOGUES
  申请人：INSTYTUT FARMACEUTYCZNY

  公开号：US20150031898A1

  公开（公告）日：2015-01-29

  A convergent synthesis of the prostaglandin F 2α analogues, travoprost and bimatoprost, was developed employing Julia-Lythgoe olefination of the structurally advanced phenylsulfone with an enantiomerically pure aldehyde ω-chain synthon. The novel convergent strategy allows the synthesis of a whole series of prostaglandin analogues of high purity from a common and structurally advanced prostaglandin intermediate.

  开发了一种收敛合成前列腺素F2α类似物travoprost和bimatoprost的方法，利用Julia-Lythgoe烯烃化反应将结构先进的苯基砜与对映纯的醛ω-链合成子进行反应。这种新颖的收敛策略允许从一个共同且结构先进的前列腺素中间体合成一系列高纯度的前列腺素类似物。
• AMINO ACID SALTS OF PROSTAGLANDINS
  申请人：DeLong Mitchell A.

  公开号：US20100105775A1

  公开（公告）日：2010-04-29

  The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.

  本发明涉及新型氨基酸前列腺素盐及其制备和使用方法。