1-(3-二甲基氨基-丙基)-5-氧代-吡咯烷-3-羧酸 | 94108-46-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 1-(3-二甲基氨基-丙基)-5-氧代-吡咯烷-3-羧酸
• 英文名称: 1-[3-(dimethylamino)propyl]-4-pyrrolidin-2-one carboxylic acid
• 英文别名: 1-[3-(Dimethylazaniumyl)propyl]-5-oxopyrrolidine-3-carboxylate
• CAS: 94108-46-0
• 化学式: C₁₀H₁₈N₂O₃
• mdl: MFCD04989727
• 分子量: 214.265
• InChiKey: MUPFIGLSLOVQLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(3-二甲基氨基-丙基)-5-氧代-吡咯烷-3-羧酸 在 草酰氯 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 生成 hexadecyl 1-[3-(dimethylamino)propyl]pyrrolidin-2-one 4-carboxylate
  参考文献：
  名称：

  [EN] 2-PYRROLIDONE DERIVATIVES FUNCTIONALIZED WITH AN ESTER, ACID OR AMIDE RADICAL, COSMETIC COMPOSITION COMPRISING THEM AND USE THEREOF FOR CONDITIONING KERATIN MATERIALS
  [FR] COMPOSITION COMPRENANT AU MOINS UNE 2-PYRROLIDONE FONCTIONNALISÉE EN POSITION 4 AVEC UN ACIDE CARBOXYLIQUE OU UN AMIDE, UTILE POUR LE TRAITEMENT APRÈS-SHAMPOOING DE MATÉRIAU KÉRATINIQUE

  摘要：

  该发明涉及使用从2-吡咯烷酮衍生的化合物，该化合物在4位上与酯基、羧酸基或酰胺基官能团发生作用，用于化妆处理角蛋白材料，特别是用于调理角蛋白材料，尤其是在人类角蛋白纤维（如头发）的梳理、拉直、易梳性和易管理性方面。该发明还涉及新型阳离子单吡咯烷酮衍生物和包含它们的化妆品组合物。除了角蛋白纤维的柔软度外，如前所述定义的化合物（I）还可以改善头发的梳理、拉直、易梳性和易管理性；头发的造型更容易，头发触感非常愉悦、流畅。

  公开号：

  WO2011154457A1
• 作为产物：
  描述：

  N,N-二甲基-1,3-二氨基丙烷 在 sodium hydroxide 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 29.0h， 生成 1-(3-二甲基氨基-丙基)-5-氧代-吡咯烷-3-羧酸
  参考文献：
  名称：

  [EN] 2-PYRROLIDONE DERIVATIVES FUNCTIONALIZED WITH AN ESTER, ACID OR AMIDE RADICAL, COSMETIC COMPOSITION COMPRISING THEM AND USE THEREOF FOR CONDITIONING KERATIN MATERIALS
  [FR] COMPOSITION COMPRENANT AU MOINS UNE 2-PYRROLIDONE FONCTIONNALISÉE EN POSITION 4 AVEC UN ACIDE CARBOXYLIQUE OU UN AMIDE, UTILE POUR LE TRAITEMENT APRÈS-SHAMPOOING DE MATÉRIAU KÉRATINIQUE

  摘要：

  该发明涉及使用从2-吡咯烷酮衍生的化合物，该化合物在4位上与酯基、羧酸基或酰胺基官能团发生作用，用于化妆处理角蛋白材料，特别是用于调理角蛋白材料，尤其是在人类角蛋白纤维（如头发）的梳理、拉直、易梳性和易管理性方面。该发明还涉及新型阳离子单吡咯烷酮衍生物和包含它们的化妆品组合物。除了角蛋白纤维的柔软度外，如前所述定义的化合物（I）还可以改善头发的梳理、拉直、易梳性和易管理性；头发的造型更容易，头发触感非常愉悦、流畅。

  公开号：

  WO2011154457A1

文献信息

• COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED IN THE 4 POSITION WITH A CARBOXYLIC ACID OR AMIDE, AND AT LEAST ONE DIRECT DYE OR A PIGMENT FOR DYEING KERATIN FIBRES
  申请人：Sabelle Stéphane

  公开号：US20130167307A1

  公开（公告）日：2013-07-04

  The invention relates to a composition for dyeing keratin fibres, and in particular human keratin fibres such as the hair, comprising at least one 2-pyrrolidone functionalized in the 4 position with a carboxylic acid or amide radical, and at least one hydrophobic direct dye or a pigment; a dyeing process using this composition. Similarly, the invention relates to the use of the said pyrrolidone combined with a direct dye or a pigment for dyeing keratin fibres, and especially to the use of the said pyrrolidone for improving the colour uptake onto the fibres of direct dyes that are sparingly soluble or insoluble in aqueous-alcoholic supports. The invention also relates to novel pyrrolidone derivatives. The present invention makes it possible in particular to obtain direct dyeing on keratin fibres that is fast, resistant to washing, chromatic and powerful.
• US8585779B2
  申请人：——

  公开号：US8585779B2

  公开（公告）日：2013-11-19
• [EN] COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED IN THE 4 POSITION WITH A CARBOXYLIC ACID OR AMIDE, AND AT LEAST ONE DIRECT DYE OR A PIGMENT FOR DYEING KERATIN FIBRES<br/>[FR] COMPOSITION CONTENANT AU MOINS UNE 2-PYRROLIDONE FONCTIONNALISÉE EN POSITION 4 PAR UN ACIDE CARBOXYLIQUE OU UN AMIDE ET AU MOINS UN COLORANT OU UN PIGMENT DIRECT POUR COLORER LES FIBRES DE KÉRATINE
  申请人：OREAL

  公开号：WO2011154460A1

  公开（公告）日：2011-12-15

  The invention relates to a composition for dyeing keratin fibres, and in particular human keratin fibres such as the hair, comprising at least one 2-pyrrolidone functionalized in the 4 position with a carboxylic acid or amide radical, and at least one hydrophobic direct dye or a pigment; a dyeing process using this composition. Similarly, the invention relates to the use of the said pyrrolidone combined with a direct dye or a pigment for dyeing keratin fibres, and especially to the use of the said pyrrolidone for improving the colour uptake onto the fibres of direct dyes that are sparingly soluble or insoluble in aqueous-alcoholic supports. The invention also relates to novel pyrrolidone derivatives. The present invention makes it possible in particular to obtain direct dyeing on keratin fibres that is fast, resistant to washing, chromatic and powerful.
• [EN] 2-PYRROLIDONE DERIVATIVES FUNCTIONALIZED WITH AN ESTER, ACID OR AMIDE RADICAL, COSMETIC COMPOSITION COMPRISING THEM AND USE THEREOF FOR CONDITIONING KERATIN MATERIALS<br/>[FR] COMPOSITION COMPRENANT AU MOINS UNE 2-PYRROLIDONE FONCTIONNALISÉE EN POSITION 4 AVEC UN ACIDE CARBOXYLIQUE OU UN AMIDE, UTILE POUR LE TRAITEMENT APRÈS-SHAMPOOING DE MATÉRIAU KÉRATINIQUE
  申请人：OREAL

  公开号：WO2011154457A1

  公开（公告）日：2011-12-15

  The invention relates to the use of compounds derived from 2-pyrrolidone functionalized in position 4 with an ester, carboxylic acid or amide radical, for cosmetically treating keratin materials, especially for conditioning keratin materials, and in particular in terms of the disentangling, straightening, combability and manageability of human keratin fibres such as the hair. The invention also relates to novel cationic monopyrrolidone derivatives and to a cosmetic composition comprising them. Besides the suppleness of the keratin fibre, the compounds of formula (I) as defined previously also make it possible to improve the disentangling, straightening, combability and manageability of the head of hair; the shaping of the head of hair is easier, and the hair has a very pleasant, fluid feel.

  该发明涉及使用从2-吡咯烷酮衍生的化合物，该化合物在4位上与酯基、羧酸基或酰胺基官能团发生作用，用于化妆处理角蛋白材料，特别是用于调理角蛋白材料，尤其是在人类角蛋白纤维（如头发）的梳理、拉直、易梳性和易管理性方面。该发明还涉及新型阳离子单吡咯烷酮衍生物和包含它们的化妆品组合物。除了角蛋白纤维的柔软度外，如前所述定义的化合物（I）还可以改善头发的梳理、拉直、易梳性和易管理性；头发的造型更容易，头发触感非常愉悦、流畅。