代谢
单次低剂量（5 mg/kg）、单次高剂量（250 mg/kg）和一系列剂量（5 mg/kg）口服给予CD大鼠放射性标记的四氯化乙烯。它几乎被完全代谢，大部分标记在给药后48小时内通过尿液（46-60%）和粪便（38-56%）排出。只有少量在组织中找到。回收的未代谢母体化合物非常少。代谢过程产生了许多不同的代谢物，并没有全部被识别。在粪便中观察到的的主要代谢物是三氯苯乙醇，女性排出的这种代谢物（占总给药C的18-34%）比男性（占13-23%）在所有三个剂量水平上都多。三氯苯乙醇也在粪便中发现，男性中占4-7%，女性中占3-6%。尿液中的主要代谢物，三氯扁桃酸，在男性中排出19-26%，但在女性中只排出10-12%。在高剂量下，女性排出的去甲基四氯化乙烯（25%）比男性（11%）多。然而，对于低剂量组，男性和女性之间几乎没有差异，男性排出8%，女性排出7%。
Radiolabelled tetrachlorvinphos was given orally to CD rats as a single low dose (5 mg/kg), as a single high dose (250 mg/kg), and in a series of doses (5 mg/kg). It was almost completely metabolized and most of the label was excreted in urine (46-60%) and feces (38-56%) within 48 hours of dosing. Only minor amounts were found in the tissues. Very little unmetabolized parent compound was recovered. The metabolic processes produced a number of different metabolites which were not all identified. The major metabolite observed in feces was trichlorophenylethanol with females eliminating more of this metabolite (18-34% total administered C) than males (13-23%) at all three dosing levels. Trichlorophenylethandiol was also found in feces ranging from 4-7 % in males and 3-6 % in females. A major metabolite in urine, trichloromandelic acid, was excreted in males at 19-26% but only 10-12% in females. At the high dose, females excreted more (25%) desmethyl tetrachlorvinphos than males (11%). However, there was essentially no difference for the low dose group with males (8%) and females (7%.)
来源:Hazardous Substances Data Bank (HSDB)
